Introduction Severe infection from the SARS-CoV-2 virus is associated with various manifestations, including hematological manifestations. Thrombotic events or a tendency to develop thrombotic events also characterize severe COVID-19 disease and may be related to fatalities. Vitamin D is known to have immunomodulating properties and to enhance the body defense system against invading pathogens and to have immunostimulatory properties as far as the innate immune response is concerned.
Aim The aim of the study was to measure 25(OH)D3 levels in patients hospitalized for severe COVID-19 infection and to investigate the relationship between 25(OH)D3 levels and ferritin levels and d-dimer levels in this cohort.
Methods. In a cohort of 42 patients hospitalized for severe infection from the SARS-CoV-2 virus 25(OH)D3 levels were measured. In the same cohort ferritin levels and d-dimer levels were also measured. Observations were also performed in a control group.
Results 25(OH)D3 levels were 8.08±1.48 ng/ml (mean±S.E.M.) and they were inversely related to ferritin levels, correlation coefficient −0.15, P=0.001, linear regression analysis and to d-dimer levels, correlation coefficient −0.34, P<0.001, linear regression analysis.
Conclusions Severe infection from the SARS-CoV-2 virus is related to a tendency for the development of thrombotic events. D-dimer levels are measured and followed in these patients. Ferritin levels are also increased in severe SARS-CoV-2 infection and may be related to adverse outcome. We showed that vitamin D levels are low in hospitalized patients with severe SARS-CoV-2 infection and are inversely related to ferritin and d-dimer levels. It may thus be proposed that vitamin D is an inverse index of severity in the context of SARS-CoV-2 infection.
21 May 2022 - 24 May 2022