ECE2022 Eposter Presentations Calcium and Bone (114 abstracts)
Correlation between vitamin D levels and severity of COVID 19 disease. Argentine Experience
María Laura García 1 , Ana Paula Lisdero 1 , Evangelina Giacoia 2 , Franco López 3 , Mauro Cruceño 2 , Valeria Pollini 4 , Marcia Esposito 5 , Mariana Scarabino 6 , Susana Bacigaluppi 7 & Aizhar Giselle Mumbach 7
1Sanatorio Méndez, Endocrinology, Buenos Aires, Argentina; 2Hospital Posadas, Endocrinology, Argentina; 2Hospital Posadas, Endocrinology, Argentina; 4Hospital Morón, Argentina; 5Sanatorio Anchorena, Argentina; 6Sanatorio Méndez, Internal Medicine, Argentina; 7Sanatorio Méndez, Endocrinology, Argentina.
Objective Vitamin D (VD) plays a role in immune response. Recent data shows that low levels of VD could worsen COVID-19 outcomes. This study aimed to establish an association between VD levels among COVID-19 patients with clinical outcomes and inflammatory markers.
Methods Prospective multicentric cohort study. Consecutively recruitment. Patients were grouped according admission status and level of VD [sufficient >30 ng/ml (VDS), insufficient 20–30 ng/ml (VDI), deficient <20 ng/ml (VDD)]. The variables evaluated were age, gender, oxygen mask requirement (O2r), mechanical ventilation (MV), pre-existing comorbidities, inflammatory markers, severity of COVID-19 measured by News Score.
Results 363 patients were recruited (age 53±16), 59% male, 88% from total were hospitalized, whose VD levels were significantly lower than ambulatories (19±11 vs. 24.3±14 ng/ml P:0.006). The amount between groups was VDS (15%), VDI (27%), VDD (58%).VD levels correlated negatively with hospitalization days and evolution time (P:0.045-P:0.043). Severity of COVID-19 adjusted by comorbidities was linked to a lower VD status (P:<0.001) Also an association with pronation requirement among patients with lower VD levels (P: 0.008) was observed. O2r risk was elevated among VDI (OR 2.9 95%CI 1.3–7) and VDD (OR 3 95%CI 1.4–6), multiplying the odds in 2.6 and 3.7 in presence of 1 or more comorbidities with a higher need of ICU in VDD groups (OR 4.8 95%CI 1.2–20). A negative relation between VD levels, basal ferritin and LDH was described (P:0.018 and P:0.045).
Conclusion Among COVID-19 hospitalized VD level was significantly lower than ambulatory patients. There is an association between low VD with a worse course of disease needing more days of hospitalization, thus lengthening the time of sickness. VDI and VDD group had severe forms of COVID-19. VDD presented a higher risk for ICU attention. Further studies are needed to emphasize the importance of adequate levels of VD to improve COVID-19 outcomes.
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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