Endocrine Abstracts

Introduction: Musculoskeletal pain is a major problem for hemodialysis patients. So, we have to control it, to ameliorate their life quality.

Aim: The purpose of this study was to evaluate the prevalence musculoskeletal symptoms and their relation with chronic hemodialysis.

Methods: This is a cross sectional study conducted in rheumatology department of Taher Sfar university hospital in mahdia, Tunisia. The study involved 61 patients with chronic hemodialysis. They were invited to participate and were included after signing informed consent until the calculated sample size was reached. Clinical and demographic characteristics were recorded, as well as years of hemodialysis duration. We asked the patients HAD score, and DN4.

Results: 61 patients were included 26 females (42,6%) and 35 males (57.4%). The mean age of the study group was 53.9 [17-83]. The mean age of onset of nephropathy was 44.7+/- 15.4 years, the medium duration of dialysis: 6,1 years. Musculoskeletal manifestation was noted in 49 (80,3%) patients, the bone pain was noted in 32 patients (52,5%) 20 patients (32,8%) had diffuse bone pain, 34 (55,7%) patients had myalgia, 24 patients (39,3%) had muscular weakness, 14,3% had neuropathic pain, 3 patients (4,9%) have jobs, 12 patients (19,7%) are retired, 46 patients (75,4%) are unemployed. The mean HAD score was 17,88 and 33 patients (54,1%) with HAD score over 19. The mean duration of dialysis in symptomatic patients and asymptomatic patients 7,01 years vs 3,24 years (P<0,005). The mean HAD score of symptomatic patients and asymptomatic patients 18,81 vs 14,04 (P<0,005).

Conclusions: Our study shows the important damage of chronic kidney disease on the musculoskeletal system that can affect patients’ quality of life and professional life. That’s why mineral and bone disorders in advanced CKD should be well managed.