ECE2022 Eposter Presentations Diabetes, Obesity, Metabolism and Nutrition (318 abstracts)
Comparative analysis of characteristics of pregnant women with pathological oral glucose tolerance test vs negative oral glucose tolerance test in a trimester of 2019
Víctor José Simón Frapolli 1 , José Ignacio Martínez Montoro 1 , María José Picón César 1 , Carolina Gutiérrez Repiso 1,2 , María Suárez Arana 3 , Francisco José Tinahones Madueño 1,2 & María Molina Vega 1
1Hospital Universitario Virgen de la Victoria, Endocrinology and Nutrition Clinical Management Unit, Málaga, Spain; 2CIBER Fisiopatología de la Obesidad y Nutrición-CIBEROBN; 3Hospital Regional Universitario de Málaga, Gynecology and Obstetrics Clinical Management Unit, Málaga, Spain
Introduction: Gestational diabetes mellitus (GDM) is the metabolic disorder most frequently associated with pregnancy, presenting important maternal and fetal implications. Strict glycemic control through lifestyle measures and/or pharmacotherapy is essential to achieve adequate obstetric-perinatal results. The objective of this study is to compare baseline characteristics and perinatal results in patients diagnosed with GDM after performing oral glucose tolerance test (OGTT) vs patients with negative OGTT, in a trimester of 2019.
Materials and method: Retrospective observational study comparing baseline clinical-laboratory characteristics and obstetric-perinatal results of 258 women referred to our center during the September-October-November trimester of 2019 due to a positive O’Sullivan test to perform the confirmatory test with 100-g OGTT.
Results: Exposed in Table 1. Of the 258 OGTT performed, 217 were negative and 41 were positive (16% positive). Among the most relevant findings, the BMI before pregnancy of the 41 women diagnosed with GDM was 29.08±5.82 kg/m2 compared to 27.64±7.03 kg/m2 in the 217 with negative OGTT (P=0.046). Weight gain during pregnancy was significantly lower in the group with GDM (P=0.001): 6.79±5.3 kg vs 10.33±5.26 kg. Of the 41 women diagnosed with GDM, 11 received treatment with insulin, 1 with metformin and 29 with dietary measures. No differences were found in obstetric or perinatal outcomes in both groups.
| Pathological OGTT (n=41) | Negative OGTT (n=217) | p | |
| Previous BMI (kg/m2) | 29,08±5,82 | 27,64±7,03 | 0,046 |
| History of GDM (n=111) | 4 | 8 | 0,142 |
| History of DM (n=224) | 14 | 46 | 0,075 |
| Weight gain (kg) | 6,79±5,3 | 10,33±5,26 | 0,001 |
| Treatment with insulin | 11 | ||
| Treatment with metformin | 1 | ||
| Treatment with diet | 29 | ||
| Birth gestational age (weeks) | 38,95±1,61 | 38,76±1,87 | 0,748 |
| Prematurity (n=228) | 2 | 18 | 0,902 |
| Newborn weight | 3258±449 | 3258±579 | 0,906 |
| Newborn height | 50,2±1,95 | 49,8±2,44 | 0,630 |
| Births (n=224): eutocic; instrumental, cesarean | 19; 5; 11 | 109; 22; 58 | 0,889 |
| Fetal percentile | 53,52±27,92 (n=34) | 54,86±30,36 (n=183) | 0,773 |
| Neonatal hypoglycemia; neonatal jaundice; distress | 2 (n=35); 3 (n=41); 0 (n=35) | 2 (n=178); 9 (n=217); 14 (n=179) | 0,130; 0,634; 0,580 |
| Neonatal admission; neonatal ICU admission; deaths | 4 (n=35); 0 (n=35); 0 (n=34) | 14 (n=179); 8 (n=177); 2 (n=179) | 0,336; 0,230; 0,706 |
| Dystocia | 1 (n=35) | 1 (n=177) | 0,304 |
Conclusion: Through diagnosis and treatment of GDM, perinatal and obstetric results achieved were similar to those of women without GDM. Although women diagnosed with GDM started with higher BMI values, they presented significantly less weight gain during pregnancy than those with negative OGTT, after undergoing a specific treatment
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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