Endocrine Abstracts

Diabetes mellitus is a metabolic disease that is accompanied by brain injury manifested as cognitive, emotional and vascular impairment.

Purpose: To study prevalence and degree of disorders of central nervous system in children with diabetes mellitus type I (TIDM).

Objects and methods: Examination of nervous system in 100 children - age 7-18 yrs [9.0-17.8] with TIDM was provided. The control group consisted of healthy children (n=30). The condition of central nervous system was determined on the basis of cognitive and emotional function tests; studying of cerebral circulation was performed using extracranial Doppler study according to standard techniques. The degree of compensation of diabetes was estimated according to criteria ISPAD Consensus Guidelines (2018).

Results: Optimal level (HbA1c<7.0%) of compensation was revealed in 62% of children (group I) and nonoptimal in 38% of children (group II). Decrease of cognitive functions, disturbance of emotional sphere and deterioration of cerebral circulation was established in 12 children (19%) in group I and 16 patients (42%) in group II (P=0.02). The performed correlation analysis revealed association of cognitive, emotional dysfunction and cerebral circulation disorders with the HbA1_c level (r=–0.41; –0.5 and –0.47 accordingly, P 0,001).

Conclusions: Diabetic children with nonoptimal HbA1_c level frequently cognitive, emotional and cerebral circulation disorders (42%). Prevalence of cognitive, emotional and cerebral circulation increased parallel to HbA1_c level.