Endocrine Abstracts

Background: Patients with type 1 diabetes have a significantly higher risk of coronary events, as well as diseases of the cardiovascular system.Purpose of the study – to show the relationship between metabolic, structural, and functional parameters of the cardiovascular system in young patients with DM1.

Methods: The study included 60 patients without CVD: 40 patients with DM1 and 20 patients without DM1, the groups were comparable in age, sex, AMT, heart rate, blood pressure\. All patients underwent a laboratory examination, which also included an assessment of the levels of adiponectin, resistin, electrocardiography, bioimpedancemetry, ergospirometry.

Results: In the group of patients with DM1, an increased content of adipose tissue (P=0.036) was revealed in the absence of a statistical difference with the group without DM in terms of BMI and correlations between the level of maximum power of exercise performance (METs) with the content of muscle tissue P=0.09 and with adipose tissue P=-0.049. In the control group, correlations were revealed - METs to % of muscle tissue P=0.004. The decrease in the functional parameters of the cardiorespiratory system in young patients with DM is noteworthy: the time to reach the anaerobic threshold (AP) (P=0.008) and the maximum oxygen consumption (VO2 max) (P=0.034), compared with the group of patients without DM1. Correlations were revealed in the group of patients with DM1: METs to VO2 max P=0.001 and to AP P=0.004. In the control group: METs to VO2max P=0.001, to AP P=0.008 and VO2max to AP P=0.003.It should also be noted an increase in the level of resistin in the group of DM1 patients compared with the group without DM1 (P=0.044). When conducting a correlation analysis In the group of patients with DM1, a correlation was found between VO2max and the level of adiponectin P=0.021.

Conclusions: Young patients with DM1 have lower functional indicators of the cardiorespiratory system, compared with patients without DM, while maintaining a high tolerance to physical activity. Also, in young patients with DM1 who do not have cardiovascular diseases, there is a significant increase in the level of resistin, which has pro-inflammatory activity and, according to many studies, is associated with an increase in cardiovascular risk.