Endocrine Abstracts

Introduction: In recent decades, metabolic diseases have continued to increase. Several investigations concerning the origin of these diseases such as dyslipidemia, hypercholesterolemia, diabetes, etc., have been elucidated. These pathologies have been attributed to lifestyles and mainly to diet. Obesity is a serious metabolic and energy disorder, which has become a real major public health problem. Materials and methodsWe were interested in studying the effect of a high-fat diet on liver function, as well as the effect of the extract on rats receiving a hyperlipidemic diet. The variations in liver toxicity parameters in the different groups were highlighted by the study of biochemical parameters and confirmed by the study of liver histology. ResultsUnder our experimental conditions, the obese had a significant elevation of serum levels of AST, ALT, LDH and CPK of 32%, 31%, 43% and 22%, respectively. While, administration of the extract to the obese improved all indices of liver toxicity. Histological sections of the livers of rats subjected to a hyperlipidemic diet for 42 days showed the appearance of lipid droplets which correspond to a deposit of fat in the hepatocytes. Whereas, CNSP and orlistat exerted a protective effect against the development of non-alcoholic hepatic steatosis in HFD-rats, objectified by a notable decrease in lipid vacuolations. ConclusionFinally, we noted that the result of these positive effects of the CNSP studied on hepatic toxicity was translated by restoring effects of the histological organizations of the liver, making them comparable with those of normal controls. This confirms the important role of this natural product in the fight against oxidative stress and the prevention of hyperlipidemia.