Endocrine Abstracts

MS, is defined by a combination of abnormalities, such as obesity, arterial hypertension, elevated blood sugar and cholesterol levels, type 2 diabetes mellitus and is not a disease, but represents a group of risk factors that often occur together, increasing the likelihood of severe disease. It is well known that the main reasons for the increase in the incidence of MS is a decrease in physical activity with a high-calorie diet.

The aim of the study: Assessment of biochemical parameters in the pathogenesis of MS.

Materials and methods: 70 MS patients and 45 practically healthy volunteers were examined at the clinic of the Research Institute of MPS. The glucose level was determined by the glucose oxidant method, lipid profile assessment, the use of standard test systems. Insulin was determined by enzyme immunoassay using the DRG test system. All study participants signed an informed consent approved by the ethics committee of the Federal Research Center. Statistical data processing was carried out using the application packages ‘Statistica for Windows 8.0’.

Results: The main diagnostic criterion for MS is abdominal obesity, it is important to find out the cause of obesity, which may be associated, for example, with diseases of the endocrine system, in combination with a number of additional symptoms confirmed by tests. It is known that insulin resistance is one of the most important links in the pathogenesis of MS, and the calculated coefficient HOMA-IR was used to assess it. This coefficient is of the greatest diagnostic value and has received wide practical application at the present time. The calculation of HOMA-IR revealed an almost 2-fold increase in this indicator in patients with MS (P<0.05), which is a predictor of the risk of developing vascular and diabetic complications. The level of NEFA in patients with MS was increased in 97% of cases and was almost 2 times higher than the normal values. Also, in patients with MS, there was an increase in the content of insulin and glucose in the blood in comparison with the control group (P<0.05).

Conclusion: The study shows that early diagnosis of MS is important for providing timely medical care and lifestyle correction and preventing the development of severe vascular and diabetic complications.