Endocrine Abstracts

The purpose of the study is to study the results of the biochemical investigation of the patients with diabetic foot syndrome and chronic kidney disease (CKD).

Material and research methods: A study was conducted 60 patients with diabetes mellitus type 2 (DM 2) with diabetic foot syndrome (DFS) in the late complications stage accociated with chronic kidney disease. All observed patients will be divided into 3 groups:

1 gr. - 20 patients with DFS, complicated by ulcers, gangrene and amputation and in combination with HBP 4-5 stages on hemodialysis

2 gr. - 20 patients with DFS, complicated by ulcers, gangrene and ammputation in combination with CKD 4-5 stages without hemodialysis

3 gr - 20 patients with DFS, complicated by gangrene and amputation, without CKD.

A group of control will be 20 healthy faces. The investigationn methods included biochemical (bilirubin, lipid spectrum, ALT, AST, blood sugar, HbA1C, urea, creatinine, etc) and instrumental (: ECG, MRI of foots, Dopplerography of the legs vessels, ultrasound of the internal organs, etc)investigation

Results: Patients with 1 and 2 groups have revealed a reliable increase in urea levels and creatinine in the blood. The average of the blood urea in group 1 reached 15.6 mmol/l, in the second 26, 5 mmol l, in group 3 - 3.4 mmol/l (normally 2.1 - 8, 2 mmol/l). The average blood creatinine values were 167, 8 mcmol/l in group 1, 188, 7 mcmol/l in 2 groups and 35.6 mcmol/l in 3 groups in men (normally 77-127 in men and 44-96 мсmol/l in women). The average value of creatinine in women group reached 101, 4 mcmol l, in group 2 - 126.7 mcmol/l and in group 3 - 49 mcmol/l\. The value of the HbA1C achieved in groups of values 9, 2%, 10, 4% and 10, 6%, respectively.

Conclusions: In patients with diabetic foot syndrome and CKD IV-V st. without hemodialysis, reliably worst indicators were revealed in comparison with patients with DFS and CKD IV-V st without hemodialysis and patients with DFS without CKD.