Endocrine Abstracts

Introduction: Diabetes insipidus during pregnancy is rare (4/100,000 pregnancies) generally occurring in the last two trimesters. It can be a previous diabetes insipidus, revealed by pregnancy, or a gestational diabetes insipidus. It would be secondary to the plasma degradation of antidiuretic hormone by placental vasopressinase.

Observation: We report the case of a 34-year-old patient, with no history of head trauma, radiation, infiltrative or autoimmune disease. who presents for a polyuro-polydipsic syndrome evolving since the second trimester of her pregnancy, with inputs at 5 liters per day and outputs at 7 liters. At the paraclinical level: Natremia at 134 mmol/l, with normal serum potassium at 4.4 mmol/l, low natriuresis at 20 mmol/24 h, plasma osmolarity at 285 mOsmo/l, and low urinary osmolarity at 160 mOsmo/l, Hypothalamo-pituitary MRI was without abnormalities, the patient was started on desmopressin nasally, the pregnancy was carried to term, with a cesarean delivery without insidents, giving birth to a new born female of 3500 g the postpartum evolution was marked by the disappearance of the polyuro-polydipsic syndrome after the second week

Conclusion: Gestational diabetes insipidus is therefore a polyuro-polydipsic syndrome which appears in pregnant women due to a deficiency in antidiuretic hormone. Rather rare, it usually disappears within three weeks after delivery.