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Endocrine Abstracts (2022) 81 EP997 | DOI: 10.1530/endoabs.81.EP997

ECE2022 Eposter Presentations Thyroid (219 abstracts)

Influence of the mother’s history during pregnancy on the development of hyperthyroidism in children living in conditions of iodine deficiency

Shakhlo Muratova 1 , Anvar Alimov 1 & Shakhnoza Azimova 2


1Republican Specialized Scientific and Practical Medical Center of Endocrinology named after academician E. Kh. Turakulov of the Ministry of Health of the Republic of Uzbekistan, Thyroidology, Tashkent, Uzbekistan; 2Republican Specialized Scientific and Practical Medical Center of Endocrinology named after academician E. Kh. Turakulov of the Ministry of Health of the Republic of Uzbekistan, Pediatric Endocrinology, Tashkent, Uzbekistan


Our goal was to determine the anamnestic characteristics of mothers during pregnancy in children with hyperthyroidism living in conditions of iodine deficiency, which possibly contribute to the development of hyperthyroidism in patients of the pediatric group.

Materials and methods of research: the analysis of the anamnesis of mothers during pregnancy of 146 children and adolescents with hyperthyroidism. The control group consisted of 97 relatively healthy children under 18 whose parents agreed to participate. Statistical processing of the results was carried out using the statistical software packages ‘SPSS 23 for Windows’ (‘IBM Corp. Armonk’, NY, USA).

Results: Analysis of the mother’s anamnesis during pregnancy of children and adolescents with hyperthyroidism are presented in Table 1. The results obtained indicate that the presence of autoimmune thyroid disease in the mother increases the risk of developing hyperthyroidism in the child by 7.5-8.2 times (OR = 8.2 (95% CI 3.1-21.5), P<0.001), while endemic maternal goitre during pregnancy and systemic autoimmune diseases (OR = 2.6 (95% CI 0.7-9.4), P=0.69) is not a reliable provoking factor (OR = 1.4 (95% CI 0.5-3.8), P=0.36). In addition, overweight and obesity (OR = 3.9 (95% CI 1.1-13.6), P=0.03), as well as anemia of varying severity in pregnant women (OR = 5.8 (95% CI 2.2-15.4), P<0.001) may increase the risk of developing hyperthyroidism in children. At the same time, vitiligo (0.7%), type 2 diabetes mellitus (2.1%), polycystic ovary syndrome (0.7%) were diagnosed only in mothers whose children had hyperthyroidism.

Table 1 Anamnesis of the mother during pregnancy of the studied children
n%Chi-squareр
Graves’ diseaseHyperthyroidism117,50
Control00
Autoimmune thyroiditisHyperthyroidism4530,8<0,001***
Control55,2
Diffuse goitre endemicHyperthyroidism128,20,36
Control66,2
Systemic autoimmune diseasesHyperthyroidism117,50,69
Control33,1
VitiligoHyperthyroidism10,70
Control00
Type 2 diabetes mellitusHyperthyroidism32,10
Control00
Overweight, obesityHyperthyroidism16110,03*
Control33,1
Polycystic ovary syndromeHyperthyroidism10,70
Control00
AnaemiaHyperthyroidism3524<0,001***
Control55,2

Conclusion: possible factors that increase the risk of developing hyperthyroidism in children living with iodine deficiency are the following maternal anamnestic indicators during pregnancy: Graves’ disease, autoimmune thyroiditis, overweight and obesity, anaemia of pregnancy, type 2 diabetes mellitus, vitiligo and polycystic ovary syndrome.

Volume 81

European Congress of Endocrinology 2022

Milan, Italy
21 May 2022 - 24 May 2022

European Society of Endocrinology 

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