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Endocrine Abstracts (2022) 81 OC5.6 | DOI: 10.1530/endoabs.81.OC5.6

1Centro Hospitalar do Tamega e Sousa, Endocrinology, Portugal; 2Centro Hospitalar do Tamega e Sousa, Gynaecology and Obstetrics, Portugal; 3Maternidade Bissaya Barreto, Centro Hospitalar e Universitário de Coimbra, Obstetrics, Portugal

Introduction: Gestational diabetes (GD) is a known risk factor for delivery, fetal and perinatal complications. Fetal male sex is known to be associated with worse perinatal outcomes, such as macrosomia, neonatal hypoglycemia, low Apgar scores, birth defects and mortality. However, studies evaluating the impact of fetal sex on perinatal outcomes in women with GD are scarce.

Objectives: We aimed to study whether male newborn sex is associated with neonatal outcomes, in women with GD.

Methods and Methods: Retrospective study based on the national register of GD. Included women with live-born singleton pregnancies followed between 2012 and 2017. Excluded women without data on variables of interest. Primary endpoint: Neonatal hypoglycaemia, neonatal macrosomia, respiratory distress syndrome (RDS) and neonatal intensive care unit admission (NICUA). BMI as pregestational weight divided by squared height. Female and male newborns were compared. Multivariate logistic regression models were built and included variables with different distribution between groups and with known association with the endpoint under analysis.

Results and Conclusions

We studied a total of 10768 newborns in mothers with GD, 5635 (52.3%) male, 438 (4.1%) had neonatal hypoglycaemia, 406 (3.8%) were macrosomic, 671 (6.2%) had RDS, and 671 (6.2%) had a NICUA. Male sex newborns were heavier, more frequently small and large for gestational age. No differences were observed on maternal age, BMI, HbA1c, anti-hyperglycaemic treatment, pregnancy complications or gestational age at delivery. In the multivariate regression analysis, male sex was independently associated with neonatal hypoglycaemia [OR 1.27 (IC 95%:1.04-1.55), P=0.02], neonatal macrosomia [1.98 (1.58-2.48), P<0.001], NICUA [1.27 (1.06-1.55), P=0.01] and RDS [1.33 (1.03-1.71), P=0.03]. Male newborns from mothers with GD have a 27% higher risk of neonatal hypoglycaemia, almost 2-fold higher risk of macrosomia, 33% higher risk of RDS and 27% higher risk of NICUA.

Volume 81

European Congress of Endocrinology 2022

Milan, Italy
21 May 2022 - 24 May 2022

European Society of Endocrinology 

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