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Endocrine Abstracts (2022) 81 P363 | DOI: 10.1530/endoabs.81.P363

1National Institute of Nutrition, Outpatient Department and Functional Explorations, Tunis, Tunisia; 2National Institute of Nutrition, Department of Diabetology and Therapeutic Dietetics, Tunis, Tunisia

Background: Lower extremity artery disease (LEAD) is a common complication of diabetes, with increasing prevalence with duration and/or the coexistence of other cardiovascular risk factors. The Ankle-brachial index (ABI) is the first diagnostic step after clinical examination, for screening and diagnosis of LEAD. The aim of our study was to evaluate the ABI in a group of long-standing type 1 diabetic patients.

Methods: We conducted a cross-sectional study at the National Institute of Nutrition of Tunis. We included type 1 diabetic patients who had diabetes for more than 20 years. We measured the brachial systolic pressure using the tourniquet and the Doppler probe and the posterior tibial systolic pressure. A high ABI (>1.30) suggests the presence of mediacalcosis. An ABI ≤0.90 indicates the presence of LEAD.

Results: We included 155 type 1 diabetic patients with mean age39.7±9.8 years. The population was predominantly female (67.1%). Mean duration of diabetes was 27.33±6.38 years [ext : 20–48 years]. Mean glycatedhemoglobin (A1c)was 9.45±1.62%. The mean ABI was 1.22 ± 0.25 with extremes ranging from 0.76 to 2.18. The majority had an ABI between 0.9 and 1.3. An ABI > 1.3 was found in 18.6% of patients. Only 5.2% of patients had an ABI < 0.9. The ABI was correlated with age (r=0.360; P<0.001) and duration of diabetes (r=0.398; P<0.001). It was inversely correlated with insulin dose (r=-0.279; P=0.006).

Conclsion: Most patients with LEAD are asymptomatic. Patients with diabetes are at higher risk of chronic limb-threatening ischaemia as the first clinical manifestation of LEAD, supporting regular screening with ABI measurement for early diagnosis.

Volume 81

European Congress of Endocrinology 2022

Milan, Italy
21 May 2022 - 24 May 2022

European Society of Endocrinology 

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