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Endocrine Abstracts (2022) 81 P368 | DOI: 10.1530/endoabs.81.P368

Hospital Universitario Virgen de la Victoria, Endocrinology and Nutrition, Málaga, Spain

Introduction: Vitamin D is considered a fat-soluble vitamin and a fundamental prohormone in mineral and bone metabolism, with an immunoregulatory, cardiovascular and neuroprotective effect, among others. Vitamin D can be found as vitamin D2 or ergocalciferol and vitamin D3 or cholecalciferol. The main source of vitamin D comes from ultraviolet radiation in sunlight, but it is also obtained through food. Vitamin D deficiency is very prevalent in Europe, with a significant peak in Spain among the pregnant and infant population, being associated with adverse maternal-fetal effects such as gestational diabetes mellitus (GDM), deficit of bone mineralization in the newborn and increased risk of preeclampsia.

Material and method: Retrospective observational study that analyzes the data of 148 pregnant women, with a mean age of 33.32±5.29 years, who came to our service to undergo 100g-SOG as a diagnostic test for GDM. Pregnant women were classified into 3 categories based on serum vitamin D levels (≤20 ng/ml, 20–29.99 ng/ml, ≥30 ng/ml), and different clinical, obstetric and perinatal variables were compared. In addition, the correlation of these variables with vitamin D levels was studied.

Results: No statistically significant differences were observed between serum vitamin D levels and the prevalence of GDM, BMI prior to pregnancy, blood pressure, HOMA-IR, total cholesterol, LDL, triglycerides, or newborn weight, among others. However, an elevation of HDL is observed in the pregnant group with higher levels of vitamin D, and an inverse correlation is observed between vitamin D and BMI prior to pregnancy, but not with the rest of the variables.

n=148Vit D ≤20 ng/ml (n=45)Vit D 20–29.99 ng/ml (n=71)Vit D ≥30 ng/ml (n=32)Chi2, ANOVA (p)Pearson correlation (p)
GDM12 (26.7%)17 (23.9%)13 (40.6%)0.234
BMI prior to pregnancy (kg/m2)28.22±8.127.36±6.324.94±4.10.107-0.2 (0.03)
Systolic blood pressure (mmHg)110.2±11.8110.6±12.9110.6±17.10.9880.006 (0.94)
Diastolic blood pressure (mmHg)71.78±9.471.92±8.469.97±10.40.587-0.001 (0.99)
HOMA-IR2.33±2.22.38±1.32.06±1.40.670-0.07 (0.39)
Total cholesterol (mg/dl)258.7±46.1256.37±47.7243.39±35.30.303-0.12 (0.14)
HDL (mg/dl)77.53±15.978.9±16.770.19±15.00.042-0.13 (0.10)
LDL (mg/dl)143.44±40.2136.85±38.6134.58±32.40.542-0.10 (0.22)
Triglycerides (mg/dl)203.64±77.2194.93±49.1193.42±45.30.677-0.05 (0.54)
Newborn weight (kg)3.18±0.43.17±0.43.17±0.40.990
Delivery (week of pregnancy)39.35±1.638.82±1.638.61±2.50.403

Conclsion: In our population, no differences were found between clinical, perinatal and obstetric parameters according to vitamin D levels. Vitamin D levels were only inversely correlated with BMI prior to pregnancy.

Volume 81

European Congress of Endocrinology 2022

Milan, Italy
21 May 2022 - 24 May 2022

European Society of Endocrinology 

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