ECE2022 Poster Presentations Diabetes, Obesity, Metabolism and Nutrition (202 abstracts)
The role of endocrine disruptors, obesity, and cytokines in PCOS
Michaela Duskova 1,2 , Jana Vítků 1 , Lucie Kolátorová 1 , Jana Vrbíková 3 , Michala Vosátková 3 , Josef Včelák 3 & Marketa S.imková 1,4
1Institute of Endocrinology, Department of Steroids and Proteofactors, Praha, Czech Republic; 2General Teaching Hospital, Third Medical Department − Department of Metabolism and Endocrinology, Praha, Czech Republic; 3Institute of Endocrinology; 4University of Chemistry and Technology, Praha, Czech Republic
As genetic and environmental components contribute to the PCOS expression, we compared levels of endocrine disruptors, steroid hormones, cytokines, and metabolic parameters in twenty healthy, nine normal-weight PCOS women, and ten obese PCOS women. Steroid hormones, bisphenols (BPA, BPS, BPF, BPAF) and parabens (methyl-, ethyl-, propyl-, butyl-, benzyl-parabens) were measured by liquid chromatography-tandem mass spectrometry. Differences between the groups were assessed using the Mann-Whitney U test. Spearman correlation coefficients were calculated for the individual parameters relationship. Significantly higher levels of BPA, Anti-Müllerain hormone, lutropine, lutropine/folitropine ratio, testosterone, androstenedione, 7β-OH-epiandrosterone, and cytokines (IL-6, VEGF, PDGF-bb), were found in normal-weight PCOS women compared to controls. In PCOS women concerning the weight, there were no differences in hormonal, but in metabolic levels. Obese PCOS women had significantly higher insulin resistance, fatty-liver index, triglycerides, cytokines (IL-2, IL-13, IFN-γ). In healthy, but not in PCOS, women, there was a positive correlation of BPA with testosterone, SHBG with lutropine, and folitropine, while testosterone negatively correlated with SHBG. In obese women with PCOS, insulin resistance negatively correlated with SHBG and estradiol. No differences were observed in the paraben exposure. Levels of BPA were higher in PCOS women, indicating its role in the etiology. Obesity significantly worsens the symptoms.
Acknowledgements: This study was supported by the Ministry of Health of the Czech Republic (MZ ČR − RVO; Endokrinologický ústav - EÚ, 00023761).
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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