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Endocrine Abstracts (2022) 81 P628 | DOI: 10.1530/endoabs.81.P628

National Institute of Nutrition, Department C, Tunis, Tunisia

Introduction: Type 1 diabetes (T1DM) is an autoimmune disease in 90% of cases and is frequently accompanied by other autoimmune diseases.

Objective: To assess the frequency of autoimmune diseases in type 1 diabetics and study the particularities of this association.

Patients and Method: This is a retrospective study including 120 type 1 diabetic patients hospitalized in department C of the National Institute of Nutrition in Tunis.

Results: The mean age of our patients was 30± 12 years with a sex ratio M/F=0.7. The average duration of diabetes was 12± 8 years. The mean glycated hemoglobin (HbA1c) was 10.3%. The frequency of autoimmune diseases was 20% with a higher incidence in women: 79% vs 21% men. Hypothyroidism topped the list with a frequency of 13.3%. The frequency of hyperthyroidism, celiac disease and Addison’s disease was 4.3%, 3.3 % and 1.6% respectively. The frequency of Biermer’s disease was the same as that of vitiligo : 0.83%. The following associations were noted: Hypothyroidism and celiac disease with a frequency of 0.83%. Hyperthyroidism and celiac disease with a frequency of 0.83%. Hypothyroidism, celiac disease and Addison’s disease with a frequency of 0.83%.

Diabetes type 1 preceded dysthyroidism in 85% of cases and other autoimmune diseases elicited in 100% of cases. Patients with associated autoimmune diseases were older (34.4 ± 12 vs. 29.1 ± 13 years; P=0.008) and had older diabetes (14 ± 11 vs. 10 ± 9 years; P=0.005).

Conclsion: The coexistence of autoimmune diseases in the type 1 diabetic patient is not rare, the practitioner is encouraged to screen them at least, as soon as diabetes is discovered and in front of evocative signs.

Volume 81

European Congress of Endocrinology 2022

Milan, Italy
21 May 2022 - 24 May 2022

European Society of Endocrinology 

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