Endocrine Abstracts

Introduction: Dyslipidemia in type 1 diabetic patients is a frequent situation and seems to be a risk factor for the occurrence of degenerative complications. The aim of this study is to evaluate the lipid profile of type 1 diabetic patients and to study the relationship between dyslipedmia and the occurrence of degenerative complications.

Method: This is a retrospective study conducted at the National Nutrition Institute of Tunis including 110 diabetic patients during the year 2021.

Results: The population consists of 45 men and 65 women, with mean age of 30+/- 12 years. The average duration of diabetes was 12 +/- 8 years. The majority of patients had poorly controlled diabetes with a mean HB1AC of 10.3 +/- 2%. Hypertriglyceridemia was present in 25.5% of patients. Moreover, hyper-LDL cholesterol and hypo-HDL cholesterol were noted in 42.7% and 32.4% of patients respectively. A significant association was noted between hypo-HDL cholesterol and diabetic nephropathy (P=0.035), diabetic retinopathy (P=0.025) and diabetic neuropathy (P=0.017). In addition, hper LDL cholesterol was associated with diabetic nephropathy (P=0.003). However, no association was found between hypertriglyceridemia and microangiopathic complications.

Conclusion: Dyslipidemia is common in type 1 diabetes and the lipid profile in type 1 diabetic patients influences the occurrence of degenerative complications of diabetes.