ECE2022 Poster Presentations Late-Breaking (41 abstracts)
Insulin-Like Growth Factor-I might be a predictor for severe nonalcoholic fatty liver disease in morbidly obese patients
Seda Turgut 1 , Didem Acarer Bugün 1 , Hakan Seyit 2 , Naim Pamuk 1 , Hamide Pişkinpaşa 1 , Evin Bozkur 1 , Mehmet Karabulut 2 & İlkay Çakır 1
1University of Health Science Bakırköy Dr. Sadi Konuk Training and Research Hospital, Endocrinology and Metabolism, Istanbul, Turkey; 2University of Health Science Bakırköy Dr. Sadi Konuk Training and Research Hospital, General Surgery, Istanbul, Turkey
Aim: To compare the IGF-1, metabolic and clinical parameters among the ultrasonographically classified NAFLD groups, to examine the effect of weight loss on metabolic parameters and determine the factors that may predict the NAFLD severity in morbidly obese patients who underwent bariatric surgery.
Method: This descriptive cross-sectional study was conducted in 316 morbidly obese patients (250 females, 66 males). The data of patients before and 1st year after bariatric surgery were included in the study. According to the NAFLD assessment, patients were classified as normal (Group 1, n=57), mild and moderate (Group 2, n=219), or severe (Group 3, n=40). IGF-1 standard deviation score (SDS) levels were calculated according to age and gender. Preoperative and postop 1st-year clinical and metabolic parameters and factors that could predict the presence and severity of NAFLD were evaluated in all groups.
Results: IGF-1 levels were significantly associated with severe NAFLD compared with the normal group, and the significance remained between the same groups when IGF-1 levels were standardized as SDSIGF1. Moreover, liver diameter explained 50% of severe NAFLD than the normal group and %13 of severe NFLAD compared to mild-moderate NAFLD. FPG, ALT, AST, and GGT were also significant predictors for severe NAFLD compared to the normal and mild-moderate NAFLD groups.
Conclusion: Together with liver diameter, FPG, AST, ALT, and GGT, IGF-1 is among important predictors of NAFLD in bariatric surgery candidate morbidly obese patients. Further studies are needed to validate the clinical utility of IGF-1 in the presence and staging in NAFLD patients.
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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