ECE2022 Rapid Communications Rapid Communications 12: Reproductive and Developmental Endocrinology (8 abstracts)
Ethinyl estradiol in a combined contraceptive exerts greater effect on serum proteome than estradiol valerate – a randomized trial
Marika Kangasniemi 1 , Riikka Arffman 1 , Sakari Joenväärä 2,3 , Annina Haverinen 4 , Kaisu Luiro 4 , Tiialotta Tohmola 2,3 , Risto Renkonen 2,3 , Oskari Heikinheimo 4 , Juha Tapanainen 4 & Terhi Piltonen 1
1Oulu University Hospital, University of Oulu, Department of Obstetrics and Gynecology, PEDEGO Research Unit, Medical Research Center, Oulu, Finland; 2Haartman Institute, University of Helsinki, Transplantation Laboratory, Helsinki, Finland; 3Helsinki University Hospital, HUSLAB, Helsinki, Finland; 4University of Helsinki, Helsinki University Hospital, Department of Obstetrics and Gynecology, Helsinki, Finland
Background: Combined oral contraceptives (COC) are known to have multiple beneficial effects besides contraception, but also cause some unwanted health outcomes. They interfere, for example, with metabolism, inflammation, hepatic protein synthesis and blood coagulation. COCs containing natural estrogens have recently been developed, yet little is known about their non-contraceptive effects compared to conventional COCs with ethinyl estradiol (EE). The aim of this study was to compare the impacts of COCs containing EE or estradiol valerate (EV) and dienogest (DNG) alone on the serum proteome.
Methods and findings: Fifty-nine healthy women participated in a randomized, controlled clinical trial. They were allocated to use either EE+DNG, EV+DNG or DNG alone continuously for nine weeks. Serum samples were collected before and after nine weeks of exposure. Samples from 44 women were available for this analysis (EE+DNG n=14, EV+DNG n=16 and DNG n=14). Changes in serum proteins were analyzed using quantitative label-free proteomics. Altogether, 514 different proteins were detected. Number of proteins that changed within the study groups were 145 for EE+DNG, six for EV+DNG and zero for DNG-only preparation. Significant change between the groups was detected in 70 proteins, of which 64 were detected between the EE+DNG and EV+DNG groups. Most affected pathways were the complement system, acute phase response signaling, metabolism related LXR&FXR/RXR activation, and the coagulation system.
Conclusions: The COC containing EE exerts a broader effect on serum proteome compared with EV combination or DNG-only preparation. These results signal a need for further studies comparing the clinical health outcomes between COCs containing EE and natural estrogens.
Trial Registration: ClinicalTrials.gov NCT02352090
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Endocrine Abstracts
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