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44th Annual Meeting of the European Thyroid Association (ETA) 2022

Brussels, Belgium
10 Sep 2022 - 13 Sep 2022

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Oral Presentations

Oral Session 11: Young Investigators / Basic

ea0084op-11-53 | Oral Session 11: Young Investigators / Basic | ETA2022

CD3+CD8+CD20+ T cells as a marker of the inflammatory phase in thyroid autoimmune and related polyautoimmune disorders: a pilot study

Stramazzo Ilaria , Virili Camilla , Capriello Silvia , Brusca Nunzia , Flavia Bagaglini Maria , Romeo Giovanna , Mangino Giorgio , Centanni Marco

Objectives: Human CD3+CD20+ T cells represents 3-5% of circulating T cells and may be detected in all lymphatic organs and in the cerebrospinal fluid. In healthy individuals CD3+CD20+ T cells have been shown to produce higher levels of IL-17A and/or IFN-γ than those of CD3+CD20- T cells. Some reports described the role of CD3+CD20+ T cells in autoimmune disorders such as multiple scler...

ea0084op-11-54 | Oral Session 11: Young Investigators / Basic | ETA2022

Study of target tissue-resident immune cells in graves’ disease and orbitopathy (star-GO): preliminary findings with a novel extensive immunophenotyping panel

Maioli Sara , Salvi Mario , Moschetti Giorgia , Crosti Mariacristina , Crivicich Erica , Di Marco Francesco , Curro Nicola , Dolci Alessia , Arosio Maura , Mantovani Giovanna , Dayan Colin , Geginat Jens , Muller Ilaria

Background and Aims: Graves’ disease (GD) and orbitopathy (GO) are characterised by the presence of pathological anti-thyrotropin receptor antibodies. In thyroid autoimmunity, especially GD and GO, a dysregulation of several T cell subpopulations has been proposed, especially T regulatory (Treg) and T helper 17 (Th17) cells, determining (auto)immunity inhibition and enhancement, respectively. T follicular cells (Tf) within germinal centres (GC: aggregates of lymphocytes w...

ea0084op-11-55 | Oral Session 11: Young Investigators / Basic | ETA2022

Role of NADPH oxidase 4 (NOX4) in resistance to metabolic iodine-131 radiotherapy in metastatic thyroid tumors carrying the BRAFV600E mutation

Radom Mickaelle , Harinquet Marylin , Buffet Camille , Dupuy Corinne

Radioiodine therapy (RAI): which is the cornerstone of the treatment of distant metastasis from differentiated thyroid cancers (DTC), is based on the expression of the iodine transporter NIS. The majority of DTC are papillary with BRAFV600E mutation in 45% to 60% of cases. This mutation is associated with RAI refractory DTC with a low NIS expression and a low differentiation score. The absence of RAI uptake is a major challenge for the treatment of patients. A promi...

ea0084op-11-56 | Oral Session 11: Young Investigators / Basic | ETA2022

Focusing on the role of the enigmatic TRα2 isoform in modulation of thyroid hormone action

Harting Nina , Eckhold Juliane , Sebastian Hones G. , Mittag Jens , J. Kaiser Frank

Thyroid hormones (TH) are important regulators of human metabolism and development, which modulate expression of target genes via nuclear thyroid hormone receptors (TRs). Different isoforms of these classical TRs including TRβ isoforms TRβ1 and TRβ2 as well as TRα1 were shown to be functional TH-responsive transcription factors and have been extensively studied. In contrast, the cellular function of TRα2, an alternative splice variant of TRα1, is ...

ea0084op-11-57 | Oral Session 11: Young Investigators / Basic | ETA2022

Monocarboxylate 8 transporter and deiodinase 2 deficiency impairs neurogliogesis in the adult mouse subventricular zone leading to cellular and functional alterations

Valcarcel-Hernandez Victor , Vancamp Pieter , Remaud Sylvie , Guadano-Ferraz Ana

Thyroid hormones (THs) play a crucial role orchestrating neurodevelopment, but also regulate adult brain function. Recently, the potent effects that THs exert in adult neurogenic niches have started to be uncovered in rodents. These include an important role in the modulation of progenitor generation, especially controlling whether a neural stem cell (NSC) determines to become a neuronal or an oligodendroglial progenitor in the adult subventricular zone (SVZ), the largest NSC ...

ea0084op-11-58 | Oral Session 11: Young Investigators / Basic | ETA2022

Integrated genomic, phenomic, functional and structural mapping of variants in thyroid hormone transporter MCT8

Groeneweg Stefan , Van Geest Ferdy , martin mariano , Dias Mafalda , Frazer Jonathan , Sterenborg Rosalie , de rooij linda , dolcetta-capuzzo anna , teumer alexander , Meima Marcel , Medici Marco , pablo nicola juan , marks debora , Edward Visser W.

Background: MCT8 deficiency is caused by loss-of-function (LoF) mutations in thyroid hormone (TH) transporter MCT8. Patients have developmental delay and abnormal thyroid function tests (TFTs). The large phenotypic variability is not understood. Moreover, phenotypes arising from LoF mutations could be employed to enhance understanding of physiology in the general population. Also, computational disease variant classifiers have poor predictive power to ascertain impact of MCT8 ...