Endocrine Abstracts

Objectives: Human CD3+CD20+ T cells represents 3-5% of circulating T cells and may be detected in all lymphatic organs and in the cerebrospinal fluid. In healthy individuals CD3+CD20+ T cells have been shown to produce higher levels of IL-17A and/or IFN-γ than those of CD3+CD20- T cells. Some reports described the role of CD3+CD20+ T cells in autoimmune disorders such as multiple scler...

Background and Aims: Graves’ disease (GD) and orbitopathy (GO) are characterised by the presence of pathological anti-thyrotropin receptor antibodies. In thyroid autoimmunity, especially GD and GO, a dysregulation of several T cell subpopulations has been proposed, especially T regulatory (Treg) and T helper 17 (Th17) cells, determining (auto)immunity inhibition and enhancement, respectively. T follicular cells (Tf) within germinal centres (GC: aggregates of lymphocytes w...

Radioiodine therapy (RAI): which is the cornerstone of the treatment of distant metastasis from differentiated thyroid cancers (DTC), is based on the expression of the iodine transporter NIS. The majority of DTC are papillary with BRAFV600E mutation in 45% to 60% of cases. This mutation is associated with RAI refractory DTC with a low NIS expression and a low differentiation score. The absence of RAI uptake is a major challenge for the treatment of patients. A promi...

Thyroid hormones (TH) are important regulators of human metabolism and development, which modulate expression of target genes via nuclear thyroid hormone receptors (TRs). Different isoforms of these classical TRs including TRβ isoforms TRβ1 and TRβ2 as well as TRα1 were shown to be functional TH-responsive transcription factors and have been extensively studied. In contrast, the cellular function of TRα2, an alternative splice variant of TRα1, is ...

Thyroid hormones (THs) play a crucial role orchestrating neurodevelopment, but also regulate adult brain function. Recently, the potent effects that THs exert in adult neurogenic niches have started to be uncovered in rodents. These include an important role in the modulation of progenitor generation, especially controlling whether a neural stem cell (NSC) determines to become a neuronal or an oligodendroglial progenitor in the adult subventricular zone (SVZ), the largest NSC ...

Background: MCT8 deficiency is caused by loss-of-function (LoF) mutations in thyroid hormone (TH) transporter MCT8. Patients have developmental delay and abnormal thyroid function tests (TFTs). The large phenotypic variability is not understood. Moreover, phenotypes arising from LoF mutations could be employed to enhance understanding of physiology in the general population. Also, computational disease variant classifiers have poor predictive power to ascertain impact of MCT8 ...