Endocrine Abstracts

Objectives: To systematically characterize autonomously functioning thyroid nodules (AFTN) by clinical, biological and imaging methods, cytology and histology when indicated.Design: Prospective, single-center study conducted from March 2018 until September 2021, in 901 consecutive patients with 67 AFTN evaluated.Methods: Enrolled patients underwent 99mTcO4 scintigraphy evaluation of thyroid function, ultrasound (US) usin...

Objectives: To date, there has been no population-wide data looking at the adherence to published TUS reporting guidelines for thyroid nodule malignancy risk assessment. In our health care region in 2018, two radiology groups worked closely with endocrinologists to improve the quality of their TUS reports by adhering to the 2015 ATA or the 2017 TIRADS guidelines. We aim to present the improvement in TUS reports quality with these dedicated changes.Method...

Objectives: The aim of this prospective study was to compare the diagnostic performance of 99mTc-sestaMIBI SPECT scintigraphy (sestaMIBI), 18F-fluorocholine PET/CT or PET/MR (FCH) for preoperative localization of hyperfunctioning parathyroid gland.Materials and Methods: 60 patients with biochemical evidence of primary (n=57) or tertiary (n=3 kidney transplanted patients) hyperparathyroidism were imaged prospectivel...

Background: Pediatric differentiated thyroid cancer (DTC) has an excellent prognosis, but has unknown late effects of treatment. Initial cardiac evaluation showed subclinical diastolic dysfunction in 20% of adult survivors. In this follow-up study, we determined the clinical course of this finding.Methods: This multicenter study, conducted between 2018 and 2020, re-evaluated survivors 5 years after the first evaluation. The primary endpoint was echocardi...

Objective: We developed a novel dual-component molecular assay as an ancillary method to improve clinical decision-making in patients with cytologically indeterminate thyroid nodules. The assay includes next-generation sequencing (NGS) based detection of mutations in 23 thyroid cancer related genes and digital polymerase chain reaction (dPCR) evaluation of the expression levels of a microRNA strongly associated with thyroid cancer. The method was designed as a “rule-out&#...