Oral Session 13: Basic 3

ea0084op-13-64 | Oral Session 13: Basic 3 | ETA2022

Metabolic and neuroinflammatory consequences of hypothyroidism in two mouse strains with different metabolic adaptability capacities, the C57BL/6J and the WSB/EIJ strains

Clerget-Froidevaux Marie-Stephanie , Chamas Lamis , Seugnet Isabelle , Tanve Odessa , Poirier Roseline , Enderlin Valerie

Thyroid hormones (TH), among their pleiotropic actions, play a central role in the regulation of metabolism and in cognitive functions. Indeed, hypothyroidism is associated with a decrease in energy expenditure and lipid metabolism, and an impairment of memory. Metabolic deregulations induced by a high fat diet (HFD) generate peripheral inflammation, which promotes the development of neuroinflammation in various brain regions. This inflammatory state can disrupt neuronal homeo...

0 shares

ea0084op-13-65 | Oral Session 13: Basic 3 | ETA2022

3,3’,5-triiodo-l-thyronine and 3,5-diodo-l-thyronine differentially modulate hepatic mitochondrial quality control in hypothyroid rats

Giacco Antonia , Petito Giuseppe , Mercurio Giovanna , Magnacca Nunzia , Senese Rosalba , Silvestri Elena , Cioffi Federica

Objective: The maintenance of healthy and functional mitochondrial network via mitochondrial quality control (QC) mechanisms, is critical throughout life to respond to physiological adaptations and stress. Due to their role in energy production, mitochondria are exposed to high amounts of reactive oxygen species making their DNA (mtDNA) particularly vulnerable to oxidative damage. Mitochondrial dysfunction causes altered QC mechanisms (i.e. altered biogenesis, dynamics, autoph...

0 shares

ea0084op-13-66 | Oral Session 13: Basic 3 | ETA2022

Generation of human thyroid organoids from embryonic stem cells to rescue hypothyroidism

Romitti Mirian , Tourneur Adrien , Lasolle Helene , Detours Vincent , Singh Sumeet , Refetoff Samuel , Costagliola Sabine

Organoids are tiny, self-organized three-dimensional versions of an organ that are produced in vitro. Human organoids offer unique opportunities to model the development, physiology, and diseases of human tissues while complementing animal models and reducing the need for animal testing. In the thyroid field, there is a lack of a functional human in vitro thyroid model which allows to further explore various aspects related to thyroid development and disease....

0 shares

ea0084op-13-67 | Oral Session 13: Basic 3 | ETA2022

A single cell atlas of the T3-responsive transcriptome during early cortical neurogenesis in human cerebral organoids

Opitz Robert , Fernandez-Vallone Valeria , Megges Matthias , Amber Julie Bresser Audrey , Obermayer-Wasserscheid Benedikt , Stachelscheid Harald , Kuhnen Peter

Perturbation of thyroid hormone (TH) function during prenatal brain development can cause a spectrum of neurological disorders as evident in pediatric patients with untreated congenital hypothyroidism or patients with mutations in THRA and SLC16A2 genes. However, scarcity and inaccessibility of human brain tissue from early developmental stages has been a major roadblock for experimental approaches to decipher local TH action in early development. Advanced <e...

0 shares

ea0084op-13-68 | Oral Session 13: Basic 3 | ETA2022

Abstract Withdrawn...

0 shares

Endocrine Abstracts

44th Annual Meeting of the European Thyroid Association (ETA) 2022

Oral Presentations

Metabolic and neuroinflammatory consequences of hypothyroidism in two mouse strains with different metabolic adaptability capacities, the C57BL/6J and the WSB/EIJ strains

3,3’,5-triiodo-l-thyronine and 3,5-diodo-l-thyronine differentially modulate hepatic mitochondrial quality control in hypothyroid rats

Generation of human thyroid organoids from embryonic stem cells to rescue hypothyroidism

A single cell atlas of the T3-responsive transcriptome during early cortical neurogenesis in human cerebral organoids

BiosciAbstracts