Endocrine Abstracts

Objectives: The use of levothyroxine (LT4) treatment aiming to improve fertility in euthyroid women with positive thyroid peroxidase antibodies (TPOAb), is not supported by the available evidence, however the extent to which this is applied in clinical practice is unknown. The aim of the study was to document the demographic, work-related characteristics, and therapeutic choices of European physicians in the case of euthyroid infertile women positive for TPOAb.<p class="ab...

Context/Objective: Evidence on the impact of thyroid hormone treatment (LT4) on pregnancy outcomes in women with subclinical hypothyroidism (SCH) without TPOAb remains scarce. We assessed this relationship in a single centre in a real-world setting.Design, Setting, Participants: Cross-sectional study in 1460 women screened for TSH, free T4 and thyroid peroxidase antibodies (TPOAb) at median 13 (11-17) weeks of gestation, during the period 2013-2014. Excl...

Objectives: Maternal hypothyroidism in pregnancy has been proposed to increase the risk of preeclampsia, but uncertainties persist regarding the underlying causal mechanisms. Thus, it remains unclear if an increased risk of preeclampsia in hypothyroid pregnant women is caused by the lack of thyroid hormones or by the thyroid autoimmunity per se.Methods: We performed a national and regional study in the Danish population. The national study was r...

Phthalate exposure is associated with thyroid function during pregnancy through a novel pathway as a hCG disruptor.Objectives: hCG stimulates thyroid function in pregnancy and phthalates are known thyroid disruptors. We investigated if phthalate exposure could act as a thyroid disruptor through affecting hCG.Methods: This study was embedded in the prospective Swedish Environmental Longitudinal, Mother and child, Asthma and allergy ...

Background: Postpartum depression (PPD) is a common mental health disorder with a major impact on maternal health and wellbeing and offspring development. Thyroperoxidase antibody (TPOAb) positivity is a major risk factor for postpartum thyroiditis and via this link, it is hypothesized that TPOAb positivity is a risk factor for PPD. However, the results of currently available single center studies are heterogeneous and affected by major study limitations.<p class="abstext"...