Endocrine Abstracts

The mature 37 amino acid peptide amylin is derived from the IAPP (islet amyloid polypeptide) gene and is produced in pancreatic beta-cells and – in much lower amounts – in other tissues, like the stomach, spinal ganglia and in the brain. Amylin is characterized by an interesting dichotomy because amylin has to propensity to aggregate into fibrils in some species, but on the other hand also to the physiological control of metabolism (probably in all species). These di...

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Can we drug receptors for microbially-produced metabolic hormones and for what indications? G protein-coupled receptors (GPCRs) have been a major group of druggable cell surface receptors and therapeutics targeting many hormone-activated GPCRs have been developed. A number of products of the processing and metabolism of foodstuffs act in a hormone-like manner and these include both short and medium chain length free fatty acids. Short chain fatty acids produced in large amount...