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Endocrine Abstracts (2022) 86 OP4.1 | DOI: 10.1530/endoabs.86.OP4.1

1Imperial College, London, United Kingdom; 2Imperial College National Healthcare Service Trust, London, United Kingdom

Background: Roux-en-Y Gastric Bypass (RYGB) results in sustained weight loss. Changes in food preferences and eating behaviour are postulated as possible contributing mechanisms. Post-RYGB, patients consume less sugary and fatty food. Sweet taste detection and sensitivity have been reported to be enhanced post-surgery and this may account for changes in the palatability of food. Underlying mechanisms for the changes in sweet taste function and eating behaviour are unclear.

Aims: We investigated whether the elevation in the post-prandial concentrations of the gut hormones Glucagon-Like Peptide-1 (GLP-1), Oxyntomodulin (OXM) and Peptide YY (PYY), account for the beneficial changes in sweet taste function and eating behaviour post-RYGB.

Methods: We infused GLP-1, OXM, PYY (GOP) or 0.9% Saline subcutaneously for 4 weeks in 26 obese subjects with pre-diabetes/diabetes, in a randomised single-blinded study. We reproduced the peak post-prandial concentrations of the gut hormones, as measured at 1-month in a matched RYGB cohort. A sweet taste study using the constant stimuli method of sucrose detection was carried out. Corrected hit rates for sucrose identification and sweet taste detection thresholds were recorded. The intensity and consummatory reward of sweet taste were assessed using Visual Analogue Scales (VAS) and eating behaviour was evaluated using validated eating behaviour questionnaires.

Results: We found no change in detection thresholds or corrected hit rates for sucrose detection following GOP. The intensity and palatability of sweet taste also remained unchanged on GOP. There was a significant reduction in restraint eating on GOP, comparable to the RYGB group. A trend to diminished external eating was observed with GOP while the saline group demonstrated no change in any aspect of eating behaviour.

Conclusion: Our findings suggest that the elevation in GOP concentrations after RYGB, are unlikely to account for the changes in sweet taste function after surgery but may promote restraint eating.

Volume 86

Society for Endocrinology BES 2022

Harrogate, United Kingdom
14 Nov 2022 - 16 Nov 2022

Society for Endocrinology 

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