BES2022 BES 2022 Abstracts (23 abstracts)
Relationship of time-varying parameters of glycemic control and glycation with arterial stiffness in patients with type 1 diabetes HbA1c remains valuable in a changing glycemic landscape
Helleputte Simon 1,2 , Calders Patrick 1 , Rodenbach Arthur 1 , Marlier Joke 4 , Verroken Charlotte 4 , De Backer Tine 1,3* & Lapauw Bruno 1,4*
1Faculty of Medicine and Health Sciences, Ghent University, Belgium; 2Fonds Wetenschappelijk Onderzoek (FWO) Vlaanderen, Belgium; 3Department of Cardiology, Ghent University Hospital, Belgium; 4Department of Endocrinology, Ghent University Hospital, Belgium
Aim: To investigate the relationship of arterial stiffness with short- and long-term parameters of glycemic control and glycation in patients with type 1 diabetes.
Methods: Cross-sectional study at a tertiary care centre including 54 patients with type 1 diabetes free from known CVD. Arterial stiffness was assessed with carotid-femoral pulse wave velocity (cf-PWV). Current level and 10-years history of HbA1c was evaluated, and skin advanced glycation end-products (AGEs), urinary AGEs, and serum AGE-receptor (sRAGE) concentrations. Continuous glucose monitoring (CGM) for 7 days was used to determine time in range, time in hyper- and hypoglycemia, and glycemic variability parameters.
Results: Cf-PWV was associated with current HbA1c (rs=+0.28), mean 10-years HbA1c (rs=+0.36), skin AGEs (rs=+0.40) and the skin AGEs-to-sRAGE ratio (rs=+0.40), but not with urinary AGE or serum sRAGE concentrations; and not with any of the CGM-parameters. Multiple linear regression for cf-PWV showed that the model with the best fit included age, type 1 diabetes duration, 24-hour mean arterial pressure and mean 10-years HbA1c (adjusted R2=0.645, P<0.001).
Conclusion: Long-term glycemic exposure and glycation as reflected by mean 10-years HbA1c and skin AGEs, respectively, are key predictors of arterial stiffness in patients with type 1 diabetes, while no relationship was found with any of the short-term CGM-parameters. Our findings stress the importance of early and sustained good glycemic control to prevent premature CVD in patients with type 1 diabetes and suggest that HbA1c should continue to be used in the risk assessment for diabetic complications.
Keywords: Arterial Stiffness; Glycemic Control; Glycation; HbA1c; Type 1 Diabetes; Continuous Glucose Monitoring; Time In Range.
Article tools
My recent searches
My recently viewed abstracts
Authors
Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
© Bioscientifica 2024 |
Privacy policy |
Cookie settings
BiosciAbstracts
Bioscientifica Abstracts is the gateway to a series of products that provide a permanent, citable record of abstracts for biomedical and life science conferences.
Find out more