Searchable abstracts of presentations at key conferences in endocrinology
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Belgian Endocrine Society 2022

BES 2022


ea0088001 | Abstracts | BES2022

Exercise as a non-pharmacological intervention to protect pancreatic beta cells in patients with type 1 and type 2 diabetes

de Brachene Alexandra Coomans , Corentin Scoubeau , Anyishai E Musuaya , Angela Castela , Julie Carpentier , Vitalie Faoro , Malgorzata Klass , Miriam Cnop , Decio L Eizirik

Aim of the work: Diabetes is characterized by progressive loss of functional pancreatic beta cells. None of the therapeutic agents used to treat diabetes arrest this process and preventing beta cell loss remains a major unmet need. We have previously shown that serum from 8 young healthy males who exercised for 8 weeks protects human islets and human insulin-producing EndoC-βH1 cells from apoptosis induced by pro-inflammatory cytokines or the endoplasmic reticulum (ER) st...

ea0088002 | Abstracts | BES2022

Function and composition of pancreatic islet cell implants in omentum of type 1 diabetes patients

Hulle F Van , Groot K De , R Hilbrands , de Velde U Van , K Suenens , G Stange , Mesmaeker I De , Paep DL De , Z Ling , B Roep , P Gillard , D Pipeleers , B Keymeulen , Tulleneers-Thevissen D Jacobs-

Introduction: Intraportal (IP) islet cell transplants can restore metabolic control in type 1 diabetes patients, but limitations raise the need for establishing a functional beta cell mass (FBM) in a confined extrahepatic site.Methods: This study reports on function and composition of omental (OM) implants after placement of islet cell grafts with similar beta cell mass as in our IP-protocol (2–5.106 beta cells/kg body weight)<p class...

ea0088003 | Abstracts | BES2022

A plasma miR-193b-365 signature predicts non-responsiveness to Lactococcus lactis-based antigen- specific immunotherapy in new-onset type 1 diabetes

Gabriele Sassi , Giada Licata , Giuliana Ventriglia , Darcy Ellis , Damme Niels Van , Yvan Saeys , Silvia Caluwaerts , Alessia Mori , Pieter Rottiers , Chantal Mathieu , Francesco Dotta , Conny Gysemans , Guido Sebastiani

Background and aims: Combining systemic immunomodulation with disease-relevant antigens could provide longer-term solutions for preventing and even reversing autoimmune type 1 diabetes (T1D). Our team established that a combination therapy (CT), composed of a short-course low-dose anti-CD3 treatment with oral delivery of genetically-modified Lactococcus lactis (L. lactis) bacteria secreting full proinsulin plus the anti- inflammatory cytokine IL-10 (LL-PINS+I...

ea0088004 | Abstracts | BES2022

Understanding pathogenic mechanisms and identifying therapeutic avenues in MEHMO syndrome using patient’s induced pluripotent stem cells

Hadis Shakeri , Izzet Mehmet Akcay , Mayank Bansal , Ying Cai , Chiara Vinci , Nathalie Pachera , Hanne Willems , Federica Fantuzzi , Yue Tong , Daniela Gasperikova , Miriam Cnop

Background and aims: MEHMO is an X-linked syndrome comprising Mental retardation, Epilepsy, Hypogenitalism, Microcephaly and Obesity. It is caused by a damaging p.Ile465Serfs frameshift mutation in EIF2S3 that encodes the &square; subunit of eukaryotic translation initiation factor 2 (eIF2), essential for protein synthesis and regulation of the integrated stress response. Patients with this EIF2S3 mutation also have neonatal hypoglycemia, early onset insulin-...

ea0088005 | Abstracts | BES2022

Identification of myokines potentially involved in the improvement of glucose homeostasis after bariatric surgery

Laura Orioli , Mickael Canouil , Kiswendsida Sawadogo , Lijiao Ning , Louise Deldicque , Pascale Lause , Barsy Marie de , Philippe Froguel , Audrey Loumaye , Yannick Deswysen , Benoit Navez , Amelie Bonnefond , Jean-Paul Thissen

Purpose: Our study aims to identify myokines potentially involved in improved glucose homeostasis after bariatric surgery.Methods: Obese patients were evaluated before and 3 months after bariatric surgery. Insulin resistance was assessed using the Homeostasis Model Assessment (HOMA) test. Muscle biopsies were taken from vastus lateralis. Genes encoding myokines involved in glucose homeostasis were identified using RNA-sequencing. Changes in myokines expr...

ea0088006 | Abstracts | BES2022

NET proteome and bioenergetic profile of PMA- and ionomycin-stimulated neutrophils from people with established type 1 diabetes

Samal Bissenova , Darcy Ellis , Aisha Callebaut , Guy Eelen , Rita Derua , Mijke Buitinga , Chantal Mathieu , Conny Gysemans , Lut Overbergh

Background and aims: Type 1 diabetes (T1D) is a chronic autoimmune disease, characterized by T-cell mediated destruction of the pancreatic insulin-producing beta-cells. Neutrophils, cells of the innate immune system, have been shown to infiltrate the pancreas and undergo neutrophil extracellular trap (NET) formation (NETosis). However, little is known about the involvement of neutrophils and specifically the role of NETosis in the pathophysiology of the disease. Our aim was to...

ea0088007 | Abstracts | BES2022

The impact of interferon-α on global gene expression in iPSC-derived β- and α-like cells

Sandra Marin-Canas , Florian Szymczak , Maria Ines Alvelos , Stephane Demine , Maikel L Colli , de Beeck Anne Op , Sofia Thomaidou , Lorella Marselli , Arnaud Zaldumbide , Piero Marchetti , Decio L Eizirik

Aim: IFNα is a key regulator of the initial dialogue between pancreatic β-cells and the immune system in type 1 diabetes (T1D). IFNα induces endoplasmic reticulum (ER) stress, insulitis and a massive HLA-ABC overexpression in human β-cells, three histological hallmarks of T1D. Against this background we investigated the global role of IFNα on iPSC-derived islet-like cells, used here to mimic islet cells in the early neonatal period when autoimmunity ag...

ea0088008 | Abstracts | BES2022

Glycemic control in patients diagnosed with renal cell carcinoma. A case series

Herdt C De , L Billion , Block C De

Background: Few cases have been described with a new-onset or worsening of a pre-existing diabetes mellitus in patients diagnosed with a renal cell carcinoma and amelioration of their diabetes following tumour resection.Methodology: This is a retrospective study (2003-2021) including adult cases who were diagnosed with a renal cell carcinoma, who underwent tumour resection and whom glycemic control was monitored. HbA1c was measured at 3 time intervals; 1...

ea0088009 | Abstracts | BES2022

The course and outcome of subacute thyroiditis: a retrospective analysis and predictive model

Filette Jeroen de , Mey Lynn De , Rop Jonas De , David Unuane , Kurt Barbe , Bert Bravenboer

Background: Subacute thyroiditis (SAT) is a destructive thyroiditis of probable viral origin. Thyroid dysfunction evolves through a set of stages (hyperthyroidism - hypothyroidism - euthyroidism) and is usually temporary, although some patients develop permanent hypothyroidism. The risk factors for permanent hypothyroidism remain largely unclear.Methods: A retrospective analysis of patients with SAT at the University Hospital of Brussels from 2001-2020 w...

ea0088010 | Abstracts | BES2022

The insulin sensitivity index derived from euglycemic clamps is correlated to liver fat content determined by magnetic resonance spectroscopy in type 1 diabetes*

Jonathan Mertens , Rie Braspenning , Floris Vanhevel , Maarten Spinhoven , Sven Francque , Block Christophe De

Background: Insulin resistance is proposed as a causative factor of non-alcoholic fatty liver disease (NAFLD) in the general population. Reports on NAFLD in type 1 diabetes (T1D) are increasing , but whether insulin resistance is linked to NAFLD in this population needs elucidation. Furthermore, people with T1D are an excellent model to investigate insulin resistance in relation to NAFLD without confounding by autologous insulin production.Aims and Metho...

ea0088011 | Abstracts | BES2022

Diagnosis and management of patients with primary hyperaldosteronism; a single-centre experience

L Billion , Herdt C De , E Philipse , O D'Archambeau , D Ysebaert , A Snoeckx , B Peeters , Block C De

Background: Primary hyperaldosteronism (PA) is a prevalent, but underreported syndrome. Diagnostic procedures and treatment options have been relatively constant since the development of the latest guideline of the Endocrine Society in 2016.Study objective: To clinically and biochemically describe subjects with PA who underwent a salt infusion test (SIT) or an adrenal venous sampling (AVS) in a tertiary hospital since 2009 and provide an overview of thei...

ea0088012 | Abstracts | BES2022

Changes in serum androgen levels in transgender women with and without gonadectomy

Sarah Collet , Noor Gieles , Chantal M Wiepjes , Annemieke C Heijboer , Tim Reyns , Tom Fiers , Bruno Lapauw , Martin den Heijer , Guy T'Sjoen

Introduction: Transgender women on gender-affirming hormone therapy (GAHT) with estrogens and anti-androgens have low serum androgen levels. These low levels may be associated with clinical symptoms such as depressed mood, reduced sexual desire and tiredness. Whether androgen levels change over the course of anti-androgen use and after gonadectomy, in a context of unchanged estrogen treatment, remains to be elucidated.Methods: This study is part of the E...

ea0088013 | Abstracts | BES2022

TPO antibody status prior to first radioactive iodine therapy as a predictive parameter for hypothyroidism in Graves’ disease

Sebastien Verdickt , Nes Falco Van , Carolien Moyson , Toon Maes , Crombrugge Paul Van , den Bruel Annick Van , Brigitte Decallonne

Objective: We investigated if a positive thyroid peroxidase antibody (TPO Ab) status before radioactive iodine (RAI) therapy in patients with Graves’ hyperthyroidism is a predictive factor for developing hypothyroidism after RAI.Methods: We performed a retrospective study of patients with Graves’ hyperthyroidism with known TPO Ab status, receiving a first administration of RAI. Patients from 4 thyroid outpatient centres in Belgium receiving a f...

ea0088014 | Abstracts | BES2022

Relationship of time-varying parameters of glycemic control and glycation with arterial stiffness in patients with type 1 diabetes HbA1c remains valuable in a changing glycemic landscape

Simon Helleputte , Patrick Calders , Arthur Rodenbach , Joke Marlier , Charlotte Verroken , Backer Tine De , Bruno Lapauw

Aim: To investigate the relationship of arterial stiffness with short- and long-term parameters of glycemic control and glycation in patients with type 1 diabetes.Methods: Cross-sectional study at a tertiary care centre including 54 patients with type 1 diabetes free from known CVD. Arterial stiffness was assessed with carotid-femoral pulse wave velocity (cf-PWV). Current level and 10-years history of HbA1c was evaluated, and skin advanced glycation end-...

ea0088015 | Abstracts | BES2022

Modest changes in sex hormones during early and middle adulthood affect bone mass and size in healthy men. A prospective cohort study

Thiberiu Banica , Charlotte Verroken , Guy T'Sjoen , Stefan Goemaere , Hans-Georg Zmierczak , Tom Fiers , Jean-Marc Kaufman , Bruno Lapauw

Bone metabolism in men is in part determined by sex steroid exposure. This is especially clear during puberty and senescence but it remains to be established whether declines in sex steroid levels during young and middle adulthood associate with changes in bone mass and size. This study investigated changes in bone mineral content (BMC), areal and volumetric bone density (aBMD; vBMD) and bone size in relation to sex steroid levels in 999 young adult men (age 24- 46 years) of w...

ea0088016 | Abstracts | BES2022

Mortality-related risk factors of inpatients with diabetes and COVID-19: a Multicentric Retrospective Study in Belgium

T Servais , F Laurent , C Litvine , Groote E De , V Godart , E Repetto , M Ponchon , P Chasseur , L Crenier , Eeckhoudt S Van , J Yango , P Oriot , M Gavriliu , S Rouhard , B Deketelaer , C Bugli , L Belkhir , D Maiter , M.P Hermans , JC Yombi , Laura Orioli

Purpose: We describe the characteristics and prognosis of inpatients with diabetes and coronavirus disease 2019 (COVID-19) in Belgium.Methods: We conducted a multicentre retrospective study during the first wave of the pandemic, from March 1, 2020 to May 6, 2020. Data on admission of patients with diabetes and hospitalized due to confirmed COVID-19 were collected. COVID-19 diagnosis was based on a positive polymerase chain reaction (PCR) test on nasophar...

ea0088017 | Abstracts | BES2022

Prolactinomas: our experience in Liège

M Trebillod , L Vroonen , P Petrossians

Introduction: The true prevalence of clinically relevant pituitary adenomas has been reevaluated at 1/1064 of the population (1). Among them, prolactinomas represent the majority with a prevalence of 1/2000. They occur usually in females, aged 20–50 Y.O., and 80% are microadenomas. Nearly 5% of prolactinomas appear in a familial or genetic setting (MEN-1 or FIPA) (2). Cabergoline is proposed as the first line therapy and is usually efficient to normalize prolactin (PRL) l...

ea0088018 | Abstracts | BES2022

A rare cause of Cushing syndrome

Bastiaan Sol , Marilyn Carpriaux , Leu Nico De

Introduction: Diagnosis of Cushing Syndrome (CS) is challenging due to its various non-specific symptoms, and multiple endogenous and exogenous causes. The incidence of endogenous CS is rare and estimated at 2 to 3 cases per million inhabitants per year in Europe (1). Primary bilateral macronodular adrenal hyperplasia (PBMAH) is an uncommon cause of endogenous ACTH-independent CS. It is a benign condition, characterized by the presence of bilateral macronodules (>1 cm), an...

ea0088019 | Abstracts | BES2022

A profound hypocalcaemia following parathyroidectomy. A case report

Herdt C De , E Philipse , D Ysebaert , Block C De

Background: Hungry bone syndrome is a relatively uncommon but serious complication in patients who underwent parathyroidectomy for primary hyperparathyroidism. The syndrome is described as a hypocalcaemia (corrected serum calcium<2.1 mmol/L) lasting longer than four days after parathyroidectomy in the presence of a normal or elevated parathyroid hormone (PTH). Treatment is challenging and guidelines are based on clinical experience. To restore calcium levels high doses of ...

ea0088020 | Abstracts | BES2022

A rare etiology of primary amenorrhea in a 16-year-old girl

E Nauwynck , W Staels , J De Schepper

Introduction: Premature ovarian insufficiency (POI) is a rare cause of primary amenorrhea (1,2). We report a 16-year-old girl with normal secondary sexual characteristics, but no menses due to an autoimmune POI and associated with autoimmune gastritis. This is the first report of such constellation in an adolescent – both conditions separately already being rare in the pediatric population.Case presentation: A 16-year-old girl was referred to our de...

ea0088021 | Abstracts | BES2022

Chromosome 22q11.2 deletion syndrome revealed by severe hypocalcemia and pulseless electric activity: Untangling a conglomerate of potential primary etiologic factors

Eric Balti , Dominique Ballaux , Dashty Husein , Peter Coremans

Background: chromosome 22q11.2 deletion syndrome has been reported to occur in about 1 per 347 to 992 fetuses.1 Patients present with velocardiofacial syndrome (VCFS) or DiGeorge syndrome (DS). Hypocalcemia has been reported to occur in up to 80.4% of cases.2Case report: a 28-year-old man, known with autism spectrum disorder (ASD), presented at the emergency department (ED) for muscle cramps. Medical history included chronic myeloid leukemia treated with...

ea0088022 | Abstracts | BES2022

Rapid growing thyroid nodule: the good one in the bad clothes

Marchi Lucrezia De , Filette Jeroen de , Johan Verhelst

Background: Primary thyroid lymphoma (PTL) is a rare thyroid tumor that accounts for only 5% of thyroid malignancies, but is associated with higher mortality than differentiated thyroid cancer. The major risk factor for thyroid lymphoma is the presence of Hashimoto’s thyroiditis (HT) with an estimated 60-fold increased risk. The lymphocytic infiltrate in HT appears to develop into lymphoma in a minority of patients. The differential diagnosis between Hashimoto’s thyr...

ea0088023 | Abstracts | BES2022

Is this just vitiligo? Nelson is hiding

Vis M De , S Deweer , B Velkeniers

Introduction: Autoimmune disease is a rare event occurring after remission of Cushing’s syndrome. We report on the appearance of new onset vitiligo in a patient treated for Cushing disease due to a an invasive pituitary adenoma, after bilateral adrenalectomy.Case report: A 64-year-old man presented to our endocrinology clinic with progressive lumbar pain that had developed two months earlier. He had undergone bilateral adrenalectomy for Cushing&#146...