Endocrine Abstracts

Dopamine receptor type 2 (DRD2) represents the main target for pharmacological therapy with dopamine agonists (DAs) in PRL-secreting neuroendocrine pituitary tumors (PRL-PitNET), even if about 10% of patients is resistant. A single paper recently described a somatic mutation in the gene encoding splicing factor 3B subunit 1 (SF3B1) in about 20% of patients with PRL-PitNET, that was associated with PRL hypersecretion, increased cell proliferation and invasion and reduced progre...

Background: Improved diagnostic precision is achieved with the addition of transcription factor (TF) analysis to characterise pituitary tumours. Clinicopathological studies have demonstrated a reduction in the prevalence of true null cell tumours (NC) and a rise in plurihormonal (PH) tumours, in comparison to methods based on hormone staining. There remains a high degree of heterogeneity in epidemiological and clinical patterns seen in studies. We hypothesise that variations i...

Medical treatment of acromegaly is based on either suppressing pituitary growth hormone (GH) secretion or by inhibiting GH action by preventing interaction with its receptor in order to suppress the elevated levels of insulin-like growth factor 1 (IGF1). AZP-3813 is a 16-amino acid, bicyclic peptide antagonist of the GH receptor (GHR) with KD of 1.9 nM for the human GHR. Previously, AZP-3813 was demonstrated to suppress IGF1 secretion in juvenile rats in a dose-rela...

Purpose: The present study aims to investigate the effects of hyperprolactinemia (HPRL) and its pharmacological control with Cabergoline (CAB) on the risk of fractures in male patients affected by prolactinoma.Methods: Observational single-center study was conducted on 39 male patients (median age 49±12,4 y) with prolactinoma, including 37 with macroprolactinoma and 2 with empty sellae. In patients PRL levels at diagnosis (PRL 0’), PRL at evalu...

Background: Hypophysitis is a rare group of disease characterized with infla mmation of the pituitary gland. Rarity of the disease obviates development of a treatment strategy. We aimed to present the nationwide data of the demographics, clinical and radiological characteristics, treatment modalities and responses of the patients diagnosed with hypophysitis in a retrospective manner.Methods: The endocrinology clinics all over the country were invited to ...

Introduction: Hypothalamic dysfunction (HD) during childhood can occur due to (treatment of) a suprasellar brain tumor. HD may not only result in pituitary dysfunction, but also in severe hyperphagia, decreased energy expenditure, diabetes insipidus with adipsia, disturbance of circadian rhythm, temperature dysregulation and behavioral problems. Currently there is no effective treatment for HD while HD has major impact on quality of life. To provide optimal care and to design ...