Endocrine Abstracts

The mechanisms regulating aldosterone secretion in primary aldosteronism (PA) independently from the renin-angiotensin axis include diverse genetic and molecular mechanisms. One mechanism results from the activation of aberrantly expressed GPCR which are diverse and highly prevalent in adrenal tissues of patients with PA, either from aldosteronoma or bilateral adrenal hyperplasia. The levels of expression of GPCR vary greatly between different PA tissues particularly for ACTH ...

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Pheochromocytomas/paragangliomas (PPGL) are catecholamine-producing neuroendocrine tumors that account for less than 1% of all hypertension cases. Despite their rarity, these tumors must be early detected and treated to prevent potentially life-threatening adrenergic crises. Unfortunately, PPGL are frequently unrecognized during pregnancy, leading to a high risk of either maternal or fetal complications. In return, pregnancy can trigger catecholamine secretory discharges in pa...