Endocrine Abstracts

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Laron syndrome (LS) is a rare genetic endocrinopathy that results from mutation or deletion of the growth hormone receptor (GH-R) gene. LS is the best characterized entity under the spectrum of the congenital insulin-like growth factor-1 (IGF1) deficiencies and is typically associated with dwarfism and obesity. Epidemiological studies have shown that LS patients do not develop cancer whereas heterozygous family members have a tumor prevalence similar to the general po...

Reports dating back to the 1950s have implicated human Growth Hormone (GH) in the initiation and invasive progression of several types of human cancers. A major hurdle in treating cancer is resistance to therapy. Recently, through a series of mechanistic studies using in vitro models and in silico analyses of human cancer patient databases, we have identified a covert role of GH in promoting cancer drug resistance via direct upregulation of: (i) the expression of ATP-...