Endocrine Abstracts

Denosumab is an effective treatment of osteoporosis that leads to substantial increases in bone mass and clinically important reductions in fracture risk with few side effects. Most patients should continue treatment; however, some patients may need to discontinue treatment due to co-morbidities or side effects. Furthermore, some patients want to discontinue treatment because of normal or near-normal BMD and absence of fractures after years on treatment. Unlike bisphosphonates...

Osteoporosis is characterized by decreased bone mineral density (BMD) and deterioration of bone microarchitecture increasing fracture risk. The main goal of osteoporosis treatment is preventing osteoporotic fractures. The most important predictor of treatment mediated fracture risk reduction is the increase in BMD. Treatment of osteoporosis falls into three pharmacological classes: antiresorptive agents (SERMs, oestrogen, bisphosphonates (BP), denosumab), osteo-anabolic drugs ...

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