Endocrine Abstracts

Introduction: The incidence of cancer has increased in case of diabetes, as well as the metabolic abnormalities observed during diabetes could have a critical role on carcinogen, nevertheless one should not deny the implication of common factors to diabetes and cancer (obesity, smoking, advanced age, etc).

Study objectives: Describe the biological and morphological screening methods for neoplasia in the event of weight loss concomitant with chronic glycemic imbalance.

Materials and methods: Retrospective descriptive study conducted at the endocrinology and metabolic diseases department of Casablanca, including 186 patients hospitalized for chronic glycemic imbalance with weight loss between 2018 and 2022.

Results: A total of 186 patients were included, reporting an average weight loss of 7.6 kg provided a weight loss assessment including an assay of tumor markers (CA19.9, ACE, CA15.3, CA125, PSA) and morphological minimal (thoracic X-ray and pelvic ultrasound), a specific morphological assessment was carried out in the event of an anomaly (echo-mammography, abdominal cervicothoracic computed tomography) or even a cervical–vaginal smear. The average age was 58.3 years with a female predominance, HBA1C averaged 11.7%, obesity was found in 69.2%, sedentary lifestyle in 91%, smoking in 39.6%, and alcoholism in 18.5%. Among them, 16 patients presented neoplasia including 7 pancreatic neoplasia, 5 mammary, 2 cervical–vaginal, 2 pulmonary and 1 case of esophageal neoplasia.

Conclusion: A chronic diabetic imbalance could suggest a neoplastic cause. Early screening for these neoplasia’s is important and should include a stratification model with clinical–biological criteria, and specific imaging.