ECE2023 Poster Presentations Reproductive and Developmental Endocrinology (108 abstracts)
Polycystic ovary syndrome phenotype and therapeutic outcomes
Mouna Elleuch , Hamdi Frikha , Dhoha Ben Salah , Molka Triki , Younes Ayadi , Fatma Mnif , Mouna Mnif , Nabila Rekik Majdoub , Nadia Charfi , Faten Haj Kacem Akid & Mohamed Abid
Hedi Chaker University Hospital, Department of Endocrinology, Sfax, Tunisia
Introduction: Polycystic ovary syndrome (PCOS) is a common endocrinopathy affecting women of reproductive age. PCOS has two phenotypes, obese and lean, the latter being a much less common presentation of the syndrome.
Aim: Compare PCOS outcomes in patients with obese PCOS and patients with lean PCOS.
Methods: A retrospective, single-center, descriptive and comparative study including patients with PCOS followed at the endocrinology department of Hedi Chaker University Hospital of Sfax, Tunisia. G1 included patients with obese PCOS and G2 included patients with lean PCOS.
Results: We included 50 female patients, of which 28 had obese PCOS. G1 patients had significantly higher BMI, waist circumference, weight and systolic blood pressure. Menstrual cycles disturbances was equally reported in the two groups while hirsutism was more common in G1 (96,7% vs 72.1%; P=0.019). Fertility issues were more frequent in obese PCOS patients (71.1% vs 45.2%; P=0.036). Response to therapeutic measures was more favorable among G2 patients as they had a more significant reduction in Ferryman and Gallway score (P=0.01). However, weight loss and normalization of menstrual cycles were comparable between the two groups (P=0.7 and P=0.22 respectively).
Discussion & Conclusion: PCOS phenotype seems to dictate some aspects of the therapeutic outcomes. Insulin resistance, low grade inflammation, adherence to treatment and psychosocial factors may be some of the main underlying explanations. Mackens et al. demonstrated that cumulative birth rates were lower after ovarian stimulation in obese PCOS patients. In a recent prospective study; Sachdeva et al. reported higher resistance to Clomiphene among obese PCOS patients. A phenotype-based, personalized approach needs be adopted in PCOS management.
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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