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Endocrine Abstracts (2023) 90 P324 | DOI: 10.1530/endoabs.90.P324


1University Hospital of Ioannina, Department of Endocrinology, Ioannina, Greece; 2School of Medicine - University of Ioannina, Department of Hygiene and Epidemiology, Ioannina, Greece; 3Erasmus MC - University Medical Center Rotterdam, Department of Internal Medicine, Rotterdam, Netherlands; 4University of Florence and University Hospital of Florence, Department of Biomedical - Experimental and Clinical Sciences, Florence, Italy; 5Unit of Reproductive Endocrinology - Aristotle University of Thessaloniki, 1st Department of Obstetrics and Gynecology, Thessaloniki, Greece; 6The Azrieli Faculty of Medicine - Bar-Ilan University, The Musculoskeletal Genetics Laboratory, Safed, Israel; 7University of Helsinki and Helsinki University Hospital, Children’s Hospital and Pediatric Research Center, Helsinki, Finland; 8Beth Israel Deaconess Medical Center - Harvard Medical School, Department of Medicine, Boston, United States

Introduction: Osteoporosis is a prevalent skeletal disease associated with increased fracture risk, morbidity, and mortality. Several meta-analyses have investigated the association between non-genetic, non-pharmacologic factors and osteoporosis risk.

Purpose: We aimed to perform an umbrella review of the literature to systematically evaluate the available evidence.

Methods: Meta-analyses of observational studies evaluating the association between non-genetic, non-pharmacologic factors and osteoporosis risk in mainly adult populations were identified by searching MEDLINE (via PubMed), Scopus and CENTRAL databases up to March 2022. The epidemiological validity and methodological quality of the evidence were graded based on commonly accepted criteria.

Results: Twenty-nine meta-analysis publications were identified (41 individual meta-analyses, 33 risk factors, 242 primary study comparisons). Assessed risk factors included nutritional exposures, disease entities (gastrointestinal, endocrinological, dermatological, other systems), infections, biomarkers, and lifestyle characteristics. Of the 41 meta-analyses, 2 (5%) were graded as of high validity evidence to support the association with higher osteoporosis risk (hyponatremia, peptic ulcer), and 4 (10%) as of moderate validity (lower total dairy or fruit intake, Parkinson’s disease, higher urine cadmium). Of the 29 meta-analyses, 2 (7%) were judged as of high quality (fruit intake, atopic dermatitis). Most meta-analyses evaluated as of high/moderate validity or high quality included a few primary longitudinal studies.

Conclusion: Despite the breadth of the meta-analytical literature on osteoporosis risk factors, only hyponatremia, peptic ulcer, lower total dairy or fruit intake, Parkinson’s disease, and higher urine cadmium were evaluated as of high/moderate validity. Identifying epidemiologically robust risk factors could help guide clinical practice and public health policy.

Volume 90

25th European Congress of Endocrinology

Istanbul, Turkey
13 May 2023 - 16 May 2023

European Society of Endocrinology 

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