ECE2023 Poster Presentations Calcium and Bone (83 abstracts)
Introduction: Osteoporosis is a prevalent skeletal disease associated with increased fracture risk, morbidity, and mortality. Several meta-analyses have investigated the association between non-genetic, non-pharmacologic factors and osteoporosis risk.
Purpose: We aimed to perform an umbrella review of the literature to systematically evaluate the available evidence.
Methods: Meta-analyses of observational studies evaluating the association between non-genetic, non-pharmacologic factors and osteoporosis risk in mainly adult populations were identified by searching MEDLINE (via PubMed), Scopus and CENTRAL databases up to March 2022. The epidemiological validity and methodological quality of the evidence were graded based on commonly accepted criteria.
Results: Twenty-nine meta-analysis publications were identified (41 individual meta-analyses, 33 risk factors, 242 primary study comparisons). Assessed risk factors included nutritional exposures, disease entities (gastrointestinal, endocrinological, dermatological, other systems), infections, biomarkers, and lifestyle characteristics. Of the 41 meta-analyses, 2 (5%) were graded as of high validity evidence to support the association with higher osteoporosis risk (hyponatremia, peptic ulcer), and 4 (10%) as of moderate validity (lower total dairy or fruit intake, Parkinsons disease, higher urine cadmium). Of the 29 meta-analyses, 2 (7%) were judged as of high quality (fruit intake, atopic dermatitis). Most meta-analyses evaluated as of high/moderate validity or high quality included a few primary longitudinal studies.
Conclusion: Despite the breadth of the meta-analytical literature on osteoporosis risk factors, only hyponatremia, peptic ulcer, lower total dairy or fruit intake, Parkinsons disease, and higher urine cadmium were evaluated as of high/moderate validity. Identifying epidemiologically robust risk factors could help guide clinical practice and public health policy.
13 May 2023 - 16 May 2023