ECE2023 Poster Presentations Calcium and Bone (83 abstracts)
Characteristics of hypoparathyroidism in a tertiary referral hospital
Yosra Abderrahim , Bilel Ben Amor , Marwa El Arem , Ines Bayar , Ekram Hajji , Sana Abid 1 , Héla Marmouch , Hanene Sayadi & Inès Khochteli
University Hospital Fattouma Bourguiba, Endocrinology Department, Monastir, Tunisia
Introduction: Hypoparathyroidism (HypoPT) is a rare endocrine disease characterized by abnormally low concentrations of PTH resulting in hypocalcemia. Etiologies are various and are dominated by postoperative HypoPT. HypoPT needs a lifelong treatment and follow-up in order to maintain appropriate calcium levels and prevent chronic complications.
Patients and Methods: A retrospective descriptive study was conducted at the endocrinology department in Fattouma Bourguiba University hospital.
Results: Twenty patients were included. The sex ratio was 1:3 with a mean age of 42.7±17.9 years. The age at diagnosis was between 3 and 66 years. The main found etiologies were postsurgical hypoparathyroidism in 57.9% of patients, auto-immune in 26.3% and isolated genetic hypoparathyroidism in 15.7 %. Thyroid surgery was indicated for thyroid carcinoma (36.4%), multinodular goiter (34.6%) and Grave disease (27.2%). Auto-immune HypoPT was associated to Type 1 diabetes (60%), auto-immune thyroiditis (20%), Biermer’s disease (20%) and coeliac disease (20%). The average calcium and PTH levels at diagnosis were respectively 2.07± 0.19mmol/l and 8.75±6.43pg/l. All patients were treated by calcium carbonate with a mean daily dose of 3400 mg [1000-8000] along with active vitamin D analogs (alfacalcidol) with a mean daily dose of 1μg [0.25-2]. Twenty five percent of patients needed oral magnesium supplements.
Conclusion: To achieve treatment targets, the majority of patients with HypoPT, as shown in our study, require high doses of calcium and vitamin D supplements leading to multiple daily intake of medications that impair their quality of life.
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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