ECE2023 Poster Presentations Thyroid (163 abstracts)
Cancer rate and characterstics of nodules with macrocalcification
Fatma Tuğçe Şah Ünal 1 , Asena Gökçay Canpolat 1 , Atilla Halil Elhan 2 , Selim Sevim 3 , Serpil Dizbay Sak 3 , Rifat Emral 1 , Özgür Demir 1 , Sevim Güllü 1 , Murat Erdogan 1 , Demet Çorapçıoğlu 1 & Mustafa Sahin 1
1Ankara University Faculty of Medicine, Department of Endocrinology and Metabolism, Ankara, Turkey; 2Ankara University Faculty of Medicine, Department of Biostatistics, Ankara, Turkey; 3Ankara University Faculty of Medicine, Department of Pathology, Ankara, Turkey
Aim: The aim of this study was to determine the malignant potential of thyroid nodules with macrocalcifications and to evaluate the role of other sonographic findings in the diagnosis of malignancy in thyroid nodules besides macrocalcifications.
Method: The findings of 8250 patients who applied to our outpatient clinic and underwent thyroid ultrasonography(US) between 2008 and 2021 were retrospectively reviewed. We included a total of 303 patients with 303 macrocalcified nodules (macrocalcification group) and an age- and sex matched group of 220 patients (control group) with the cytopathologic and/or histopathologic data of fine needle aspiration biopsy (FNAB) of thyroid nodules without calcification. Demographic characteristics of these patients, US characteristics of the nodules, and thyroid function tests were recorded. Cytopathological data of FNAB were classified according to BETHESDA.
Results: Overall, 458 (87.6%) of 523 nodules were benign, whereas 65 (12.4%) were malignant. When the macrocalcification and control groups were evaluated separately, 16 (7.3%) of 220 nodules in the control group were malignant, and 49 (16.2%) of 303 nodules in the macrocalcification group were malignant. Malignancy was significantly higher in the macrocalcification group than in the control group. (P=0.002) The nodules with macrocalcifications were divided into subgroups with peripheral interrupted calcifications and others according to the type of macrocalcification, and there was no association between peripheral interrupted calcification and malignancy risk. (P=0.496) We examined the sensitivity and specificity of the TI-RADS classifications. In the macrocalcification group, the sensitivity of the TIRADS classification was 54.8% (95%CI, 39.9 - 68.8%) and the specificity was 80.3% (95%CI, 74.7- 84.9%).
Conclusions: In our study, the malignancy rate was higher in the macrocalcification group than in the control group. There was no association between peripheral interrupted calcification and malignancy risk. In the macrocalcification group, the classification system TI-RADS had similar sensitivity and specificity as in the study population.
Keywords: Macrocalcification; Thyroid nodule; Ultrasonography; Thyroid cancer; TI-RADS classifications
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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