ECE2023 Rapid Communications Rapid Communications 4: Reproductive and Developmental Endocrinology (6 abstracts)
Evolution of cardiovascular risk markers in polycystic ovary syndrome: Results from a long-term monocentric cohort study
Carolina Cecchetti 1 , Srdjan Pandurevic 1 , Paola Dionese 1 , Elisabetta Belardinelli 1 , Laura Rotolo 1 , Flaminia Fanelli 2 , Luca Bergamaschi 3 , Carmine Pizzi 3 , Uberto Pagotto 1 & Alessandra Gambineri 1
1Via Giuseppe Massarenti, 9, Division of Endocrinology and Diabetes Prevention and Care, IRCCS Azienda Ospedaliero-Universitaria di Bologna, Italy;Department of Medical and Surgical Sciences (DIMEC), Alma Mater Studiorum, University of Bologna, Italy, Bologna, Italy; 2Via Giuseppe Massarenti, 9, Center for Applied Biomedical Research, Dept. Of Medical and Surgical Sciences, Alma Mater Studiorum – Bologna University, Bologna, Italy, Bologna, Italy; 3Via Giuseppe Massarenti, 9, Unit of Cardiology, Department of Specialist, Diagnostic and Experimental Medicine, Alma Mater Studiorum, University of Bologna, Italy; Department of Medical and Surgical Sciences (DIMEC), Alma Mater Studiorum, University of Bologna, Italy, Bologna, Italy
Background: Many questions concerning polycystic ovary syndrome (PCOS) remain unsolved, such as the long term evolution of cardiovascular (CV) risk markers and the risk for CV events.
Methods: A total of 119 PCOS patients diagnosed in 2009 by NIH criteria at our Unit were evaluated at baseline for cardiovascular risk markers (hypertension, diabetes mellitus-DM, dyslipidaemia, obesity, carotid intima media thickness-cIMT, and epicardial fat thickness-EFT) and cardiovascular events. All subjects were subsequently reevaluated between 2020 and 2021.
Results: Participants mean age was 39.9±7.6 years at baseline and 51.9±7.6 years at the end of the study, with a prevalence of menopausal state of 6.1% and 39.3%, respectively. At baseline, no major or minor CV events were detected, but 2 cases of angina pectoris (1.7%), 1 case of transient ischaemic attack (0.8%), 3 cases of arterial revascularization (2.5%), and 1 case of cardiac insufficiency (0.8%) were documented at the end of the study. Prevalence of hypertension, type 2 DM, dyslipidaemia, and obesity were initially 27.2%, 12.2%, 59.0% and 32.1%, and 44.4%, 18.6%, 87.2% and 47.2% at final reevaluation (P<0.001, P=0.065, P<0.001, P<0.05 vs baseline, respectively). cIMT was significantly increased at final examination (0.58±0.16 mm vs 0.81±0.27 mm, P<0.001), and the% of patients with cIMT≥ 1 mm or with carotid plaques passed from 1% to 26.4% (P<0.001). In contrast, a significant decrease in EFT was detected from baseline to the end of the study (0.86±0.35cm and 0.41±0.23cm, P<0.001).
Conclusions: This cohort study shows that PCOS is indeed characterized by a high prevalence of cardiovascular risk markers, with a tendency to increase over time; nonetheless, not all cardiovascular risk markers worsen steadily, with some interesting beneficial variations occuring in the late reproductive or early post-menopausal years.
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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