Endocrine Abstracts

Introduction: Historically, treatment of follicular thyroid carcinoma (FTC) and oncocytic thyroid carcinoma (OTC) is based on thyroidectomy followed by radioiodine (RAI) therapy. Both tumor types have a good prognosis (10-year survival 80-94%), but this changes significantly once RAI-refractory disease occurs (median 3.5 years), which limits further treatment possibilities. The main risk factors for developing RAI-refractory disease in FTC and OTC are unknown. Our aim was to i...

Objectives: Genomic instability play a role in cancer development through different mechanisms including chromosome fragility and in particular the altered telomere length (TL). Previous studies showed that the presence of short telomeres in the blood was associated with development of sporadic head and neck, bladder, lung, renal and breast cancer. In thyroid cancer, has been demonstrated that familial form of papillary thyroid cancer (FPTC) has shorter telomeres in blood leuk...

Background: The 2022 WHO Classification of Endocrine and Neuroendocrine Tumors has introduced, as other neuroendocrine neoplasms, new pathological features to classify medullary thyroid carcinoma (MTC) in low/high grade. However, whether it can be reliable in clinical practice should be confirm by further studies.Aim: To verify the predictive value of the 2022 WHO grading system in patients with MTC.Materials and Methods: Tumor tis...

Objective: We prospectively evaluated the quality of postoperative neck ultrasound (POU) for thyroid cancer patients in our healthcare region after the implementation of European Thyroid Association (ETA) guideline-based POU assessment with one radiology group in 2018.Methods: Our analysis involved 672 differentiated thyroid cancer (DTC) patients treated at our center between April 1, 2017, and March 1, 2023. POU report quality was compared between radio...

Objective: Globally, cancer is one of the leading causes of death. Therefore, identification of risk factors is of paramount interest. Whether thyroid dysfunction is a cancer risk factor is currently being debated. The aim of this study was to evaluate the risk of cancer in patients diagnosed with hypothyroidism.Methods: This is a register-based nationwide cohort study of individuals diagnosed with hypothyroidism referred to Danish hospitals (followed fr...