Endocrine Abstracts

First TBSRTC editions have made advances in problems of thyroid management. However, the real grey zone ‘AUS/FLUS’ and ‘FN/SFN’categories have been remained to be problematic with the wide range of ROMs documented in the literature alongside two editions. The ROMs of ‘AUS/FLUS’ and ‘FN/SFN’ categories were defined as 5-15% and 15-30% and the management was ‘repeat FNA’ and ‘lobectomy’ -respectively- in the first editi...

Background: Several case reports and a few studies reported that hypothyroid patients have elevated serum potassium (K+) levels. However, hypothyroidism has not been widely accepted as a cause of hyperkalemia. This study aims to determine the incidence of hyperkalemia and factors influencing serum K+ levels in thyroid cancer patients who have hypothyroidism due to thyroid hormone withdrawal before radioactive iodine (RAI) treatment.Methods: We retrospect...

Purpose: Although some studies presented good outcome of Radiofrequency Ablation (RFA) for Papillary Thyroid microcarcinoma (PTMC), its benefit has not been fully elucidated. The purpose of our study was to report the results from a prospective study investigating efficacy and safety of RFA in active surveillance candidate for low-risk PTMC. Materials and Methods: Since November 2018, RFA has been prospectively performed in active surveillance candidates...

Introduction: Thyroglossal duct cysts (TDC) are a very frequent congenital neck mass and are mostly benign. Papillary thyroid carcinoma (PTC) originating from a TDC represents an infrequent finding. Usually, the diagnosis is only made postoperatively after cyst’s excision.Case report: A 38-years old female patient was referred to the Endocrinology department due to Graves’ disease. She had been treated with antithyroid drugs for 18 months witho...

Background: Understanding of changes in salivary and lachrymal gland functions after radioiodine therapy (131I-therapy) remains limited; and, to-date no studies have evaluated dose-response relationships between absorbed dose from 131I-therapy and dysfunctions of these glands. This study investigates salivary/lachrymal dysfunctions in differentiated thyroid cancer (DTC) patients six months after 131I-therapy, identifies 131I-therapy related risk ...

Objective: Digital pathology is the process of scanning conventional slides and then digitally stitching consecutive images into digital slides that can be viewed, managed, and analyzed on a computer monitor. In this study, we evaluated the area of metastatic foci in cervical lymph node (LN) metastasis in application of digital pathology and prognostic implication for predicting structural recurrence in patients with papillary thyroid cancer (PTC).Method...

Background: Patients with type 2 diabetes (T2DM) are generally known to have increased risk of various types of cancer. However, the studies addressing the association between T2DM and thyroid cancer are heterogeneous and inconclusive. The aim of our study was to evaluate the patients who have already undergone thyroid surgery with histologically confirmed results as the ‘gold standard’.Methods: A retrospective study in 102 patients (74 women a...

Purpose: Papillary thyroid cancer (PTC) has a strong propensity for lymph node metastasis, which is related with local recurrence, and disease-specific survival in the elderly. We evaluated the association between lymph node metastasis and disease multifocality, bilaterality, and other clinicopathological variables to identify risk factors and aid surgical decision-making. The relationship between the number of foci and metastasis to cervical lymph node was also evaluated....

Introduction: Systemic treatment of advanced progressing thyroid cancer (TC) is based on molecularly targeted therapy with tyrosine kinase inhibitors (TKIs), mainly inhibitors targeting vascular endothelial growth factor receptors (VEGFR). Such treatment is related to numerous side effects. However, the relationship between TKIs and renal adverse events (RAEs) is unclear. VEGFR inhibitors are associated with proteinuria. In some patients, increased serum creatinine level and t...

Introduction: The treatment with tyrosine-kinase inhibitor drugs (1st line Lenvatinib) in patients with radioiodine-refractory differentiated thyroid cancer (I-131) and disease progression can be burdened by important side effects which often require suspension/reduction of the therapy and correct multidisciplinary management.Patients and methods: Clinical/histopathological characteristics, outcome, adverse events and the role of gender have been evaluat...