Endocrine Abstracts

Context: Prior to thyroidectomy for Graves’ disease, thyroid function should be adequately controlled to avoid complications such as thyroid storm. However, preoperative thyroid function control is sometimes difficult.Objective: This study assessed the postoperative risks are increased or not if biochemically hyperthyroid patients undergoing total thyroidectomy in comparison to euthyroid patients.Methods: A retrospective, coho...

Background: Graves’ disease (GD) is an autoimmune disorder of thyroid gland and is the first cause of hyperthyroidism. Radioactive iodine (RAI) therapy is the most used second- line treatment after failure of anti-thyroid drugs. The optimal RAI’s activity to be administered may be predetermined or calculated. Whether the latter is better is still a matter of debate.Aim: To compare the risk of persistent hyperthyroidism in GD patients treated wi...

Background: Guidelines in healthcare shall be evidence-based, satisfy patients’ needs and improve patients’ outcomes. We aimed to estimate incremental costs after the introduction of a national guideline for Graves’ disease in Sweden adding the Graves’ Recurrent Events After Therapy (GREAT) score with genetic determinants to predict recurrence, a thyroid nurse, calcium-D-vitamin treatment preoperatively, and thyroid stimulating immunoglobulins.<p class=...

Background: Mental fatigue, depression and anxiety are common in Graves’ disease (GD). Our aims were to assess the relationship between these variables among GD patients both in the hyperthyroid phase and after treatment. The pathogenic mechanisms involved in these symptoms are unknown and so is if previous psychiatric disease influences these symptoms.Methods: This was a longitudinal case control study in Göteborg, Sweden, on 65 women with new...

Objectives: Radioactive iodine (RAI) therapy has potential therapeutic effects in treating Graves’ disease (GD). However, whether RAI therapy for GD can increase cancer risk remains a controversial issue in medicine and public health.Methods: Using the Korean National Health Insurance Service-National Health Information Database (NHIS-NHID, 2002–2020), we investigated hazard ratios (HRs) of overall and site-specific cancer associated with RAI i...

Introduction: Selenium is a mineral that plays a key role in the intracellular reactions of the thyroid. Some selenium-based proteins have a protective antioxidant function in thyrocytes. Likewise, Selenium is incorporated into deiodinases, helping in the synthesis of thyroid hormones. Through its antioxidant and anti inflammatory properties, selenium affects the development of autoimmune thyroid diseases, such as Graves Disease. Supplementation with selenium is often prescrib...

Introduction: Multiple myeloma (MM) is a lethal hematological malignancy with an incidence of 6.1/100 000 per year. The association of thyroid autoimmune diseases and MM is rare and has not been fully investigated. Also, it is well known that agranulocytosis is a potential lethal adverse reaction of antithyroid treatment.Case report: We present the case of a 59-year-old female patient that presented with symptoms of hyperthyroidism. Objectively: Mild bil...

Objective: Oxidative stress has been implicated in the pathogenesis of hyperthyroidism, and its complications. Advanced glycation end products (AGEs), compounds derived from non-enzymatic transformation of macromolecules, are able to increase oxidative stress and promote inflammation and are increased in several oxidative stress-related disorders, including autoimmune thyroiditis. In the same diseases, the activity of paraoxonase-1 (PON-1), an anti-oxidant enzyme protecting ag...

Background: Graves’ disease (GD) is the most common form of hyperthyroidism in Sweden. About 2000 patients are affected by GD annually (incidence 21/100 000) and a majority are women in working age. GD can be overwhelming for the affected patient. Health care professionals do their best to meet the patients’ needs, but can we do more? The aim of this study was to explore patients’ experiences of being affected by GD to improve healthcare.M...