Amyloid goiter in patient with mediteranian fever

Meri Karapetyan; Armen Varzhapetyan

doi:10.1530/endoabs.92.PS2-14-06

PS2-14-06

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Endocrine Abstracts (2023) 92 PS2-14-06 | DOI: 10.1530/endoabs.92.PS2-14-06

ETA2023 Poster Presentations Case Reports 1 (9 abstracts)

Amyloid goiter in patient with mediteranian fever

Meri Karapetyan ¹ & Armen Varzhapetyan ²

Err

Author affiliations

¹Yervan State Medical University, Endocrinology, Armenia; ²Yerevan State Medical University, Astghik Medical Center, Endocin Surguary, Yerevan, Armenia

Introduction: The thyroid gland is affected by amyloidosis in 50% of cases in primary amyloidosis and80% in secondary amyloidosis.

Case report: The patient, male, born in 1976 was admitted to the department of endocin Surguary of the Astghik Medical Center, Armenia complaining of general weakness, feeling of compression and heaviness in the neck (cervical discomfort), cough, shortness of breath, swallowing difficulty. When the patient was 12 years old diagnosed Mediteranian Fever. The following findings have been determind.


Test	Result	Normal range
TSH	1.1 uIU/ml	0.27-4.2 uIU/ml
FT4	1.5 ng/dl	0.93-1.7ng/dl
T3	0.9 ng/ml	0.80–2.0 ng/ml
Thyroid gland ultrasound	Expressed diffuse changes of the thyroid gland with total amyloid fibrous transformation of thyroid tissue with sharply depleted vascular pattern. Right lobe: volume – 184.6 cm3, left lobe: volume – 168.5 cm3, isthmus – 10.9 mm.

Macro-preparation on cut.

DS. Mediterranean Fever, Amyloid goiter Thyroidectomy was performed.

Micro-preporation

Amyloidosis of the thyroid gland: vessel walls sharply thickened by deposits of amyloid in them. Hematoxylin and eosin.

Conclusion: Thyroid amyloidosis is a rare disease. The presence of dense rough surface progressing in size goiter, often leads to the assumption of thyroid cancer. Note that in spite of the atrophy of the glandular tissue of the thyroid gland, the patient had not expressed disturbances of hormonal status (euthyroid state). This fact may be related to powerful compensatory properties of the thyroid glandMacro-preparation on cut.DS. Mediterranean Fever, Amyloid goiterThyroidectomy was performed.Micro-preporationAmyloidosis of the thyroid gland: vessel wallssharply thickened by deposits of amyloid in them. Hematoxylin and eosin.