ETA2023 Poster Presentations Pregnancy (9 abstracts)
B cells from anti-thyroid antibody positive, infertile women show hyper-reactivity to BCR stimulation
Anna Bajnok 1 , Timea Serény-Litvai 2 , Viktoria Temesfoi 2 , Jasper Nörenberg 3 , Greta Pham-Dobor 4 , Ambrus Kaposi 5 , Akos Varnagy 3 , Kálmán Kovács 3 , Sandor Pentek 3 , Tamas Koszegi 6 , Timea Berki 7 & Emese Mezosi 8
1University of Pécs, Clinical Center, Department of Obstetrics and Gynecology, Pécs, Hungary; 2University of Pécs, Szentágothai Research Centre, Pécs, Hungary; 3University of Pécs, Department of Obstetrics and Gynecology, Pécs, Hungary; 4University of Pécs, Clinical Center, First Department of Internal Medicine, Pécs, Hungary; 5Eötvös Loránd University, Department of Programming Languages and Compilers, Budapest, Hungary; 6University of Pécs, Clinical Center, Department of Laboratory Medicine, Pécs, Hungary; 7University of Pécs, Department of Immunology and Biotechnology, Pécs, Hungary; 8University of Pecs, University of Pécs, First Department of Internal Medicine, Pecs, Hungary
Anti-thyroid antibody (ATA) positivity affects 1 out of 9 women in childbearing age and presents a significant risk for infertility. Emerging evidence indicates that alterations in the B cell receptor induced calcium (Ca2+) signaling could be key in the development of autoimmunity. We aimed to investigate the Ca2+ flux response of B lymphocyte subsets to BCR stimulation in Hashimoto’s thyroiditis and related infertility. We collected peripheral blood samples from ATA+, infertile, euthyroid patients (HIE), hypothyroid, ATA+ patients before (H1) and after levothyroxine treatment (H2), and age-matched healthy controls (HC). All B cell subsets of ATA+, infertile, euthyroid patients showed elevated basal Ca2+ level and hyper-responsivity to BCR ligation compared to the other groups, which could reflect altered systemic immune function. The Ca2+ flux of hypothyroid patients was similar to healthy controls. The levothyroxine-treated patients had decreased prevalence of CD25+ B cells and lower basal Ca2+ level compared to pre-treatment. Our results support the role of altered Ca2+ flux of B cells in the early phase of thyroid autoimmunity and infertility.
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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