Lipid profile in women with PCOS and their phenotypes

Lena Radic; Sanja Ognjanovic; Bojana Popovic; Dusan Ilic; Macut Jelica Bjekic; Kovacevic Valentina Elezovic; Palibrk Milica Opalic; Katarina Krstic; Dragan Hrncic; Milutinovic Danijela Vojnovic; Djuro Macut

doi:10.1530/endoabs.99.EP1002

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Endocrine Abstracts (2024) 99 EP1002 | DOI: 10.1530/endoabs.99.EP1002

ECE2024 Eposter Presentations Reproductive and Developmental Endocrinology (78 abstracts)

Lipid profile in women with PCOS and their phenotypes

Lena Radic ¹ , Sanja Ognjanovic ¹ , Bojana Popovic ¹ , Dusan Ilic ¹ , Jelica Bjekic Macut ² , Valentina Elezovic Kovacevic ¹ , Milica Opalic Palibrk ¹ , Katarina Krstic ¹ , Dragan Hrncic ³ , Danijela Vojnovic Milutinovic ⁴ & Djuro Macut ¹

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¹Clinic for Endocrinology, Diabetes and Metabolic Diseases, University Clinical Centre of Serbia, Department for Endocrine Tumors and Hereditary Cancer Syndromes, Belgrade, Serbia; ²Clinical Hospital Centre Bezanijska Kosa, Belgrade, Serbia; ³Institute of Physiology, Faculty of Medicine, University of Belgrade, Belgrade, Serbia; ⁴IBISS, University of Belgrade, Belgrade, Serbia, Belgrade, Serbia

Introduction: Polycystic ovary syndrome (PCOS) is one of the most common endocrine diseases among women of reproductive age and is associated with many metabolic manifestations, such as obesity, insulin resistance, dyslipidaemia and hyperandrogenism. The aim of the research was to analyse lipid profile in women with PCOS and their phenotypes.

Subjects and methods: We evaluated 159 women with PCOS diagnosed using ESHRE/ASRM criteria (PCOS: age: 25.85±5.14 years, BMI 23.75±5.54 kg/m²) and 51 BMI-matched healthy women (Controls: age: 28.02±5.35 years, BMI 23.17±4.98 kg/m²). PCOS group was divided into four phenotypes: A (anovulation (ANOV), hyperandrogenism (HA), polycystic ovary morphology (PCOM)), B (ANOV, HA), C (HA, PCOM), D (ANOV, PCOM). We measured levels of lipid indices, total testosterone, SHBG and androstenedione, while values of free androgen index (FAI) were calculated.

Results: Our analysis showed that there were significantly higher triglyceride levels in PCOS group in comparison to controls (PCOS:Controls: 0.95±0.49 vs 0.812±0.49, P=0.014), while the levels of total cholesterol, LDL and HDL cholesterol were similar in both groups (P>0.05). There were significantly higher levels of total testosterone, FAI and androstenedione (P<0.001), as well as significantly lower levels of SHBG (P<0.001) in women with PCOS. Comparison of lipid profile between PCOS phenotypes showed that phenotypes B and C differ in triglyceride levels, which were significantly higher in phenotype B (PCOS B:PCOS C: 1.10±0.51 vs 0.84±0.35, P=0.049), while the concentration of other lipid parameters between groups was similar (P>0.05 in all comparisons). Triglyceride levels showed positive correlation with FAI in PCOS phenotype B (r=0.551, P=0.018).

Conclusion: In our study we showed that there is a difference in triglyceride levels between metabolic and reproductive phenotypes of PCOS. Positive correlation between triglycerides and FAI in phenotype B represents a direct influence of the PCOS phenotype on metabolic consequences and relevant cardiometabolic outcomes during life.