Differentiated thyroid cancer in the adolescent population

Hamza Fatma; Khouloud Boujelben; Hamdi Frikha; Dhoha Ben Salah; Maalej Souhir; Elleuch Mouna; Hadjkacem Faten; Jardak Issam; Mnif Mouna; Mnif Fatma; Charfi Nadia; Guermazi Fadhel; Chtourou Khalil; Abid Mohamed; Rekik Nabila

doi:10.1530/endoabs.99.EP1205

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Endocrine Abstracts (2024) 99 EP1205 | DOI: 10.1530/endoabs.99.EP1205

ECE2024 Eposter Presentations Endocrine-Related Cancer (90 abstracts)

Differentiated thyroid cancer in the adolescent population

Hamza Fatma ¹ , Khouloud Boujelben ² , Hamdi Frikha ² , Ben Salah Dhoha ² , Maalej Souhir ² , Elleuch Mouna ² , Hadjkacem Faten ² , Jardak Issam ¹ , Mnif Mouna ² , Mnif Fatma ² , Charfi Nadia ² , Guermazi Fadhel ¹ , Chtourou Khalil ¹ , Abid Mohamed ² & Rekik Nabila ²

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¹Habib Bourguiba Hospital, Department of Nuclear Medicine; ²Hedi Chaker University Hospital, Department of Endocrinology

Introduction: Differentiated thyroid cancer (DTC) is one of the most prevalent malignant tumors in adolescents and young adults, accounting for 14-15 % of all neoplasms in this population. Patients present commonly with advanced-stage disease. The aim of our study was to highlight clinical and histopathological features of DTC in the adolescent population.

Patients and Methods: This was a retrospective study, performed in the department of nuclear medicine in Habib Bourguiba hospital –Sfax –Tunisia. Twenty patients with DTC, aged between 18 and 30 years old, were recruited between 2019 and 2020.

Results: The mean age of patients was 26.2 years old. The female sex was the most affected with a sex ratio of 1.8. Clinical features leading to the diagnosis of DTC were as follows: thyroid nodule in 11 cases, cervical lymphadenopathy in 5 cases and symptoms of hyperthyroidism in 4 cases. All our patients underwent total thyroidectomy. Cervical lymphadenectomy was performed in 78.5% of patients. Different cytological features were observed. Classic variant of DTC was the most common histological subtype (86.6%), followed by vesicular variant (15.4 %). Multifocality was noted in 54% of patients. Lymph node involvement was identified in 40% of cases. The tumor multifocality was noted in 54% of patients. Lymph node involvement was identified in 40% of cases.

Conclusion: DTC in adolescents and young adults is characterized by an important initial local and distant extension. Papillary carcinoma remains the predominant type. Then, the risk of lymphatic recurrence is high, but remains curable with a combination of surgery and radioactive iodine.