Thyroid papillary microcarcinoma: a tunisian survey

Fatma Hamza; Khouloud Boujelben; Hamdi Frikha; Salah Dhoha Ben; Arous Mohamed Khairi; Mouna Elleuch; Faten Hadjkacem; Issam Jardak; Mohamed Maaloul; Fatma Mnif; Nadia Charfi; Mouna Mnif; Fadhel Guermazi; Khalil Chtourou; Mohamed Abid; Majdoub Nabila Rekik

doi:10.1530/endoabs.99.EP1206

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Endocrine Abstracts (2024) 99 EP1206 | DOI: 10.1530/endoabs.99.EP1206

ECE2024 Eposter Presentations Endocrine-Related Cancer (90 abstracts)

Thyroid papillary microcarcinoma: a tunisian survey

Fatma Hamza ¹ , Khouloud Boujelben ² , Hamdi Frikha ² , Dhoha Ben Salah ² , Mohamed Khairi Arous ² , Mouna Elleuch ² , Faten Hadjkacem ² , Issam Jardak ² , Mohamed Maaloul ¹ , Fatma Mnif ² , Nadia Charfi ² , Mouna Mnif ² , Fadhel Guermazi ¹ , Khalil Chtourou ¹ , Mohamed Abid ² & Nabila Rekik Majdoub ²

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¹Habib Bourguiba University Hospital, Department of Nuclear Medicine; ²Hedi Chaker University Hospital, Department of Endocrinology

Introduction: Papillary thyroid carcinoma (PTC) is the most common histological form of thyroid neoplasm, increasingly diagnosed at the microcarcinoma stage (tumor diameter ≤10 mm). The majority of papillary thyroid microcarcinomas (PTMC) are not recognizable during physical exam and are commonly diagnosed fortuitously during histopathologic analysis of thyroid specimens following surgery for benign thyroid conditions. The aim of our study was to identify different clinical and pathological characteristics of PTMC.

Patients and Methods: A retrospective study including 51 patients who were followed for PTMC, at the department of nuclear medicine at Habib Bourguiba hospital, Sfax-Tunisia. Clinical, pathological and therapeutic characteristics were analyzed.

Results: The average age of patients was 44.6 ± 8,9 years. There were 46females and only 3 males PTMC was diagnosed after thyroid nodule and nodular goiter surgery in 41.25% and 23,5 % of cases, respectively. Cervical lympadenopathy was found in 25.5% of cases. Only one patient had a lymph node metastasis. All patients underwent total thyroidectomy and cervical lymphadenectomy was performed in 80 % of patients. Pathological examination revealed a vesicular variant in 23.5% of patients and a classic variant of PTC in 76.5% of patients. Multifodality was found in 68% of patients. The mean tumor diameter was of 3.9 mm (1 mm-10 mm). Lymph node involvement was confirmed in 20 % of patients. Lymphocytic thyroiditis was observed in 35.4% of patients. Capsular rupture was found in 43.1% of surgical specimens.

Conclusions: PTMC present various clinical and histopathological features that emplace them on the borderline of benignity. However, regular follow-up is of a great importance in the management of the tumors, as late recurrence may occur.