Thyroid parameters in healthy pregnant women without autoimmune thyroid disease

Violeta Mladenovic; Sanja Medenica; Zoran Gluvic; Milena Mitrovic

doi:10.1530/endoabs.99.EP146

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Endocrine Abstracts (2024) 99 EP146 | DOI: 10.1530/endoabs.99.EP146

ECE2024 Eposter Presentations Thyroid (198 abstracts)

Thyroid parameters in healthy pregnant women without autoimmune thyroid disease

Violeta Mladenovic ¹ , 2 , Sanja Medenica ³ , 4 , Zoran Gluvic ⁵ , 6 & Milena Mitrovic ⁷ & 8

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¹University Clinical Center Kragujevac, Clinic for Endocrinology, Kragujevac, Serbia; ²Faculty of Medical Sciences University of Kragujevac, Internal Medicine, Kragujevac, Serbia; ³Clinical Center of Montenegro, Department of Endocrinology, Internal Medicine Clinic, Clinical Center of Montenegro, Podgorica, Montenegro; ⁴University of Montenegro, School of Medicine, Podgorica, Montenegro; ⁵Zemun Clinical Hospital Center, Division of Internal Medicine, Deptartment of Endocrinology, Beograd, Serbia; ⁶University of Belgrade - Faculty of Medicine, Beograd, Serbia; ⁷Clinical Center of Vojvodina, Clinic for Endocrinology, Diabetes and Metabolic Diseases, Novi Sad, Serbia; ⁸Medical Faculty in Novi Sad, Novi Sad, Serbia

Introduction: Pregnancy has a significant effect on the thyroid gland and thyroid function. Thyroid hormone regulates metabolism, growth, and development in most tissues of the body, including various physiological processes. Normal thyroid function is important in order to ensure the best outcome.

Aim: The aim of this study is to analyse values of thyroid parameters during pregnancy in healthy population of pregnant woman.

Matherial and methods: The study included 77 pregnant women in the first trimester registered in Clinic for endocrinology UCC Kragujevac that were tested using OGTT, according to ADA criteria: pregestational and gestational diabetic women were excluded, and also determinaning thyroid parameters (fT4, TSH, TPOAb). The sample size included women in each trimester. We analyzed the values of thyroid parameters in 46 healthy pregnant women (without gestational diabetes mellitus and thyroid disorders including autoimmune thyroiditis). The characteristics of the participants were expressed as mean ± standard deviation.

Results: The mean age of 46 healthy pregnant women was 29.4±4.5 years. The results has been shown in the tables.

Table 1. The mean values of thyroid status parameters during pregnancy
X±SD (95%CI)	1. trimester	2. trimester	3. trimester	After delivery
fТ3 ( pg/ml)	2.67±0.49 (2.53-2.82)	2.13±0.49 (1.99-2.28)	2.15±0.45 (2.02-2.29)	2.44±0.5 (2.29-2.59)
fТ4 ( pg/ml)	10.68±2.16 (10.04-11.32)	7.58±2.11 (6.96-8.21)	7.18±1.48 (6.75-7.63)	10.48±2.27 (9.81-11.16)
ТSH(mIU/l)	2.09±1.11 (1.76-2.42)	2.59±1.47 (2.16-3.03)	2.48±1.18 (2.13-2.83)	1.97±0.89 (1.7-2.24)

Table 2 Range of values in the examined population for the movement of thyroid function parameters during pregnancy
parameter (min-max)	1. trimester	2. trimester	3. trimester	After delivery
fТ3 ( pg/ml)	1.98-3.16	1.64-2.62	1.7-2.6	1.94-2.94
fТ4 ( pg/ml)	8.52-12.84	5.47-9.69	5.7-8.66	8.21-13.11
ТSH (mIU/l)	0.98-3.2	1.12-4.06	1.3-3.66	1.08-2.86

Conclusion: This study demonstrates that as the pregnancy progresses, the average values of fT3 and fT4 decrease, and TSH increases, only to return to values similar to before pregnancy after delivery.

Keywords: thyroid parameters, pregnancy