Unusual distant metastasis of thyroid cancer: about 4 cases

Malika El Omri; Jemli S; Bellakhdher Mouna; Meherzi Abir; Houas Jihene; Ghammem Monia; Ach Taieb; Kermani Wassim; Abdelkefi Mohamed

doi:10.1530/endoabs.99.EP484

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Endocrine Abstracts (2024) 99 EP484 | DOI: 10.1530/endoabs.99.EP484

ECE2024 Eposter Presentations Thyroid (198 abstracts)

Unusual distant metastasis of thyroid cancer: about 4 cases

El Omri Malika ¹ , Jemli S ¹ , Bellakhdher Mouna ¹ , Meherzi Abir ¹ , Houas Jihene ¹ , Ghammem Monia ¹ , Ach Taieb ² , Kermani Wassim ¹ & Abdelkefi Mohamed ¹

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¹ENT department Farhat Hached Hospital, Sousse, Tunisia; ²Endocrinology Department Farhat Hached Hospital, Sousse, Tunisia

Introduction: Distant metastases of thyroid tumors are rare. They are mainly localized in the lungs (10-15%), bones (9%) and brain (1%). Metastases to the facial area are exceptional. These metastases are more common with carcinoma of the vesicular (20%) than papillary (3.5%) carcinoma. The aim of our work is to support clinical and radiological aspects as well as therapeutic modalities of these entities.

Observations: Cases 1 and 2: Woman aged 38 and a boy aged 13, admitted for a chronic dry cough. Physical examination found thyroid nodules with lymphadenopathies. Chest x-ray showed a micronodular military. They had a total thyroidectomy with bilateral functional dissection confirming multifocal papillary carcinoma. A supplement with radioactive ablation therapy was associated. Case 3: A 55 years old woman admitted for lumbosciatalgia with a motor deficit. Osteomedullar biopsy revealed a metastasis of a vesicular carcinoma of the thyroid. Additional imaging revealed 2 left thyroid nodules. The patient had a decompressive radiation followed by thyroidectomy associated with bilateral central dissection. Case 4 A 43 year old woman admitted for chronic nasal obstruction. Examination found thyroid nodules. CT showed a mass extended to the right nasal fossa, maxillary sinus, sphenoid sinus, sella turcica and associated with a right lobar thyroid mass. Biopsy was in favor of nasal infiltration by a poorly differentiated carcinoma of the thyroid. The patient had chemotherapy.

Conclusion: Distant metastases of thyroid cancers have no clinical or radiological specificity. These metastases are more frequent with the vesicular histological type and have a more guarded prognosis.