ECE2024 Eposter Presentations Thyroid (198 abstracts)
Papillary thyroid microcarcinomas and lymph node metastases: [about 20 cases]
Khouloud Boujelben 1 , Fatma Hamza 2 , Feriel Touzi 1 , Elleuch Mouna 1 , Dhoha Ben Salah 1 , Yasmine Elloumi 1 , Islam Jardak 2 , Mohamed Maaloul 2 , Mouna Mnif 1 , Fatma Mnif 1 , Charfi Nadia 1 , Faten Hadj Kacem 1 , Fadhel Guermazi 2 , Khalil Chtourou 2 , Abid Mohamed 1 & Rekik Nabila 1
1Hedi Chaker Hospital, Endocrinology Department, Tunisia; 2Habib Bourguiba Hospital, Nuclear Medicine Department, Sfax, Tunisia
Introduction: Papillary thyroid microcarcinomas (PTMC) usually manifest a slow progression, commonly displaying local-regional extension, contributing to a generally favorable prognosis. However, certain instances are complicated by lymph node metastasis, a pivotal factor influencing therapeutic strategies. The aim of this study was to evaluate the epidemiological, clinical, and histological characteristics of patients with PMCT and lymph node metastasis.
Patients and Methods: We performed a retrospective study and selected 20 patients who were diagnosed with Papillary Thyroid Microcarcinoma (PTMC) and had lymph node metastasis. These patients had undergone at least one total thyroidectomy and were referred to the nuclear medicine department of Habib Bourguiba Hospital for radioiodine therapy.
Results: In our study, there were 17 females and 3 males, resulting in a sex ratio of 5.66 The mean age was 43.4 years, ranging from 11 to 87 years Therapeutically, 13 patients underwent upfront total thyroidectomy, while lobectomy was performed in 7 patients. Totalization in the same procedure occurred in 6 cases, and later, after obtaining the definitive histological result, in only one patient. Histologically, the final examination revealed a diagnosis of classic papillary carcinoma in 85% of cases, with vesicular dedifferentiation noted in only 15%. The size of the tumor focus varied from 1 mm to 1 mm, averaging 4.1 mm. The tumor was multifocal in 17 cases. Capsular invasion was identified in 40% of cases, often associated with vascular emboli in 3 instances. All patients underwent a tracer dose scan with an average thyroglobulin (TG) level of 23.1 ng/ml. Hormonal replacement therapy was prescribed for all participants.
Conclusions: The detection of lymph node metastases heightens the risks of distant recurrence, justifying an exhaustive therapeutic strategy. Moreover, Surveillance should not be constrained temporally, as late recurrences remain a plausible occurrence
Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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