Diabetes & Metabolism

ea0104p61 | Diabetes & Metabolism | SFEIES24

Enhancement of adipose hypoxial inducible factor-1α by probiotics alleviates metabolic disturbance in experimentally induced pcos

Background: Polycystic ovarian syndrome (PCOS) is critically characterized with metabolic and endocrine dysfunctions, precipitating metabolic syndrome and infertility in reproductive aged women. Adipose tissue dysfunction has been implicated in the pathogenesis of metabolic syndrome, including in PCOS individuals. Probiotics are healthy bacteria in the gut that regulate metabolic health. However, the impact of probiotics on adipose-driven metabolic syndrome has not been report...

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ea0104p62 | Diabetes & Metabolism | SFEIES24

A quality improvement project to improve statin prescription in eligible patients with type 1 diabetes mellitus

Maher Sean , Ruddy Maria , Canavan Ronan

Background: Type 1 diabetes mellitus (T1DM) is associated with high cardiovascular risk. Statins reduce the risk of non-fatal myocardial infarction when used as a primary prevention in selected patients with T1DM. A 2020 audit of statin prescription in our department showed 28.3% of patients who met criteria were on statin therapy. The aim of this quality improvement project was to improve statin prescription in eligible patients presenting to our outpatient diabetes departmen...

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ea0104p63 | Diabetes & Metabolism | SFEIES24

Abstract withdrawn...

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ea0104p64 | Diabetes & Metabolism | SFEIES24

Knowledge of type 2 diabetes patients about hypoglycemia

Arfaoui Cyrine , Teyeb Ben Salah Zeineb , Khammassi Naziha

Background: Hypoglycemia is a common but preventable complication of type 2 diabetes. Knowledge of its causes and what patients should do is essential. The main objective of our study was to describe the level of patients knowledge about hypoglycemia. The secondary objective was to study the factors influencing this knowledge.Methods: This was a cross-sectional observational study over a period of 3 months including patients followed for type 2 dia...

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ea0104p65 | Diabetes & Metabolism | SFEIES24

Case: the glycaemic effect of GLP-1 receptor agonist semaglutide as an adjuvant therapy in HNF1-α MODY

Lonergan Eibhlin , Ng Nicholas , Slattery David

MODY as a result of a genetic variant in the HNF1-α gene is traditionally treated with sulphonylureas, often with eventual progression to insulin use due to the loss of beta cell function. We present the case of a 58-year-old female who attended the diabetes service for many years for a genetically confirmed diagnosis of HNF1-α MODY. She was originally diagnosed with pre-diabetes at the age of 16 and eventually commenced on oral hypoglycaemic agents (OHAs) at the age...

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ea0104p66 | Diabetes & Metabolism | SFEIES24

Abstract withdrawn...

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ea0104p67 | Diabetes & Metabolism | SFEIES24

Specific diet and exercise patterns exert discernible effects on acute ketone metabolism in healthy adults: a cross-over observational study

Murphy Enda , Walsh Eabha , Sayfullaeva Jessica , Alsalem Salman , Alshogairi Aseel , Lynch Caitriona , Kelly Tara , OBrien Timothy , Leahy Martin , Finucane Francis

Physiological ketosis may play an important role in human health. We sought to describe, using point of care blood ketone measurements, the time to onset of ketosis (plasma beta-hydroxybutyrate (BHB) ≥0.5 mmol/l) when fasting, and in response to various exercise and dietary scenarios following 12- and 24-hour fasts. Ten healthy female adults had BHB concentrations measured continuously over three hours during three dietary scenarios on separate mornings, after a 12-hour ...

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ea0104p68 | Diabetes & Metabolism | SFEIES24

A review of hyperglycaemia management in a Model 4 hospital Emergency Department in the Republic of Ireland

Byrne Rachel , Leavy Ciara , Shields Darragh

Background: Diabetic ketoacidosis (DKA) and Hyperglycaemic Hyperosmolar State (HHS) are serious emergencies with clear management guidelines, requiring early recognition and treatment. There are limited recommendations for uncomplicated hyperglycaemia management in the ED.Aim: To review current practices regarding management of emergency and non-emergency presentations of hyperglycaemia to St. Jamess Hospital ED.Methods: A re...

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ea0104p69 | Diabetes & Metabolism | SFEIES24

Glycaemic status, length of stay and mortality in acute pancreatitis patients admitted to intensive care

Busti Stefano , Madrid Imanol , Parker Alexander , Wilson Anthony , Tokwabilula Greg , Geraghty Joe , Thabit Hood

Background: Severe acute pancreatitis (SAP) has a high rate of mortality and complications. We evaluated the association between glycaemia, length of stay (LoS) and mortality in SAP patients admitted to our intensive care unit (ICU).Methods: Data from 91 patients admitted to ICU between December 2018 and June 2022 with a primary diagnosis of SAP were retrospectively analysed. Blood glucose levels were measured as per local standard practice. Percentages ...

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ea0104p70 | Diabetes & Metabolism | SFEIES24

Association between impaired awareness of hypoglycaemia and psychological outcomes in people living with insulin-treated type 2 diabetes

McCarthy Aisling , Divilly Patrick , Zaremba Natalie , Martine-Edith Gilberte , Soholm Uffe , de Galan Bastiaan , Pedersen-Bjergaard Ulrik , McCrimmon Rory J. , Renard Eric , Heller Simon , Evans Mark , Mader Julia K. , Amiel Stephanie A. , Pouwer Frans , Choudhary Pratik

Background: Impaired awareness of hypoglycaemia (IAH) is associated with impaired psychological health in people living with type 1 diabetes (T1D). We explored the differences in anxiety, depression and diabetes distress according to hypoglycaemia awareness in people living with insulin-treated type 2 diabetes (T2D).Methods: This analysis included 321 T2D participants from the Hypo-METRICS study. Participants completed the General Anxiety Disorder-7 (GAD...

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ea0104p71 | Diabetes & Metabolism | SFEIES24

Assessing medication adherence and identifying barriers to adherence among patients with type 2 diabetes mellitus in uzbekistan

Sultonov Asadbek , Khaydarov Mukhammadbektosh , Oblokulova Malika , Shamansurova Zulaykho , Khalimova Zamira

Introduction: Diabetes mellitus (DM) significantly impacts health in Uzbekistan, with a 7% prevalence among adults aged 20-79, affecting over 1.3 million people in 2021. The disease contributed to 16,670 deaths and incurred healthcare costs of approximately 277.6 million USD, projected to rise by 25% by 2030. Poor medication adherence can lead to severe complications such as hyperglycemia and cardiovascular diseases, making it essential to understand and improve adherence rate...

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ea0104p72 | Diabetes & Metabolism | SFEIES24

Impact of new start hybrid closed loop (HCL) insulin pump therapy on glycaemic control, diabetes distress and hypoglycaemia awareness in tallaght university hospital (TUH)

Horan Mary , Thomas Caitlin , Finn Mary , George Rexy , Kenna Celine , Morris Breda , O'Brien Ciara , Moore Kevin , Shaamile Ferrah

Background: Diabetes nurses and dietitians, with support from the endocrinology team, led a restart of the insulin pump service for pump-naïve patients in TUH in May 2023.Aim: To compare glycaemic control, diabetes distress and hypoglycaemia awareness pre and post HCL system use in the first 6 months.Research Design: Patients who had completed BERGER carbohydrate counting course, attended a carbohydrate counting refresher. Foo...

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ea0104p73 | Diabetes & Metabolism | SFEIES24

Advanced diabetes technologies for management of type 1 diabetes mellitus (T1DM) in a visually impaired person

Mc Dermott Niamh , Browne Sonya , Lee Jack , Forde Hannah , Smith Diarmuid

Background: The leading cause of visual impairment among individuals with diabetes is diabetic retinopathy. Hybrid closed-loop (HCL) therapy has revolutionised diabetes care, offering a more automated and precise approach to insulin delivery. However, these technologies can inadvertently marginalise individuals with disabilities, including those with visual impairment.Case: We present the case of a legally blind 70-year-old female with a 60-year history ...

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ea0104p74 | Diabetes & Metabolism | SFEIES24

A challenging case of adult-onset non-diabetic hypoglycemia: unveiling glycogen storage disease type vi (hers disease)

Daffaallah Hesham , Aslam Hina , Stead Bekki , Richardson Tristan

Introduction: Glycogen Storage Disease Type VI (GSD VI), typically diagnosed in childhood, is rarely identified in adults. This case highlights a 48-year-old woman with adult-onset non-diabetic hypoglycemia, who was ultimately diagnosed with GSD VI. Case Description: A 48-year-old woman presented with a ten-year history of intermittent, episodic symptoms including overnight sweating, cramps, morning fatigue, mood swings, and worsening migraines. Initial ...

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ea0104p75 | Diabetes & Metabolism | SFEIES24

An adipose organoid model for investigating adipose health and function

Luk Cheukyau , Makava Natallia , Skromna Anna , Cubbon Richard , Kearney Mark , Haywood Natalie

Background: In obesity the relationship between white adipose tissue expansion and neovascularisation becomes uncoupled leading to inadequate perfusion of adipose tissue. Under these circumstances the secretory profile of adipocytes becomes metabolically unfavourable and pro-atherosclerotic. Therefore, targeting white adipose tissue may provide a potential therapeutic strategy to combat the negative metabolic and cardiovascular consequences of obesity. Here, we validated a mur...

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ea0104p76 | Diabetes & Metabolism | SFEIES24

Investigative approach using smart insulin pens in a young person with type 1 diabetes and recurrent prolonged hypoglycemic episodes

Bonanos Stathis , Smyth Jayna , McNabb Bernadette , Birch Alison , Kinley Claire , McMullan Paul

This is a case of an 18-year-old person living with Type 1 Diabetes, presenting with unusual severe hypoglycemic episodes, on insulin Detemir twice daily and insulin Aspart with meals. Episodes appeared prolonged in duration requiring IV glucose infusions with a total of four inpatient admissions. Intentional overdose was recurrently denied, and smart insulin pen downloads confirmed normal expected insulin dosing. Investigations included a Short Synacthen Test with a stimulate...

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ea0104p77 | Diabetes & Metabolism | SFEIES24

Characteristics of hypoglycaemia and its outcomes in people with continuous glucose monitoring (CGM) devices: pilot data from the DEKODE hypoglycaemia study

Ling Jie Yee Amanda , Bal Aditya , Page Charles , Persad Kalyaani , Idrissi Mariam , Choudhary Pratik , Viswanath Iyer Pranav , Kempegowda Punith , Sherratt-Mayhew Sam , Hypoglycaemia Working Group DEKODE

Background: Continuous Glucose Monitoring (CGM) devices are increasingly used to track blood glucose levels in individuals with diabetes. Despite widespread agreement on their benefits, limited information exists regarding the characteristics and clinical outcomes when these individuals experience hypoglycemia.Objective: To investigate the characteristics of hypoglycaemia and its outcomes in people using CGM devices.Methods: This r...

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ea0104p78 | Diabetes & Metabolism | SFEIES24

Audit on recognition and management of steroid-induced hyperglycemia in tipperary university hospital

Veerasamy Kevin , Bahaledein Elgelani

Introduction: Glucocorticoid use is well-known to exacerbate uncontrolled blood sugar levels in patients with known diabetes and worsen glycemic control in non-diabetics. Steroid induced hyperglycemia (SIH) is one of the most prevalent side effects with approximately 18-52% of patients experiencing it following steroid initiation [1]. There is a lack of guidance for SIH in Tipperary University Hospital (TUH) which prompted this audit. Our aims were to identify whether SIH was ...

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ea0104p79 | Diabetes & Metabolism | SFEIES24

A retrospective look at HBA1C levels in type 1 diabetes patients in GUH pre- and post-initiation of hybrid closed loop pump therapy

Uwadoka Onyinyechi , Cunningham Aine , Griffin Tomas

Aim: To evaluate HbA1c values in patients attending the diabetes service at Galway University Hospital before and after initiating hybrid closed loop pump therapy.Background: Advancements in the treatment of Type 1 diabetes mellitus, especially the development of hybrid closed loop pump systems, have greatly improved blood glucose management. These systems automate insulin delivery based on real-time glucose readings, enhancing glycaemic control, and all...

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ea0104p80 | Diabetes & Metabolism | SFEIES24

Monitoring and management of inpatients on systemic glucocorticoids – quality improvement for inpatient care

Stephen Fuller Eoin , Mary O'Shea Kate , Pyeh Kyithar Ma

Background: Blood glucose monitoring for inpatients on systemic glucocorticoids is recommended by The Joint British Diabetes Societies for Inpatient Care, due to increased insulin resistance. Stress dosing of steroids during acute illness is recommended by the Society of Endocrinology in patients taking long-term systemic steroids due to the increased likelihood of suppressed hypothalamo-pituitary-adrenal function.Aims: We aimed to determine whether capi...

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ea0104p81 | Diabetes & Metabolism | SFEIES24

Assessing the prevalence of MASLD in a cohort of patients attending the diabetes clinic in a single centre - using the fibrosis-4 (FIB-4) index for liver fibrosis

Okiro Julie , Ibrahim Ibrahim , Kyne Niamh , Khan Waqar , Vaswani Aneel , McEvoy Robert , Forde Hannah , Smith Diarmuid

The prevalence of Metabolic Associated Steatotic Liver Disease (MASLD) is approximately 55% in patients with Type 2 diabetes (T2DM). The EASL-EASD-EASO guidelines recommend screening patients with T2DM for MASLD. Fibrosis-4 Index (FIB-4) is a simple tool used to screen for MASLD in T2DM. FIB-4 scores are characterised as; low (<1.3), moderate (1.3 2.67) or high risk (>2.67). The aim of the audit was to screen a consecutive number of patients attending the out-pa...

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ea0104p82 | Diabetes & Metabolism | SFEIES24

Monogenic diabetes screening in the midwest of ireland

Kilcoyne Ciara , Dunleavy Therese , Noctor Eoin , Rasheed Erum , Melvin Audrey

Monogenic diabetes is estimated to account for as much as 4% of childhood and adolescent diabetes. Positive test rates for monogenic diabetes in the UK have been reported as 23%1. The aim of this study was to determine positive testing rates among adults within the University of Limerick Hospital Group catchment population of approximately 413,000 people. Adults (age >16years) who underwent screening for monogenic diabetes over a 24 month (January 2021 to Decemb...

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ea0104p83 | Diabetes & Metabolism | SFEIES24

Diabetic ketoacidosis, urosepsis and emphysematous osteomyelitis in a patient on an SGLT2 inhibitor

O'Shea Kate , Crowley Rachel , O'Shea Donal , Howley Fergal

Emphysematous osteomyelitis (EO) is a rare, potentially fatal infection caused by gas forming organisms. It is characterized by the presence of intraosseous gas. Diabetes is a predisposing condition. SGLT2 inhibitors increase the risk of urinary infection and Diabetic Ketoacidosis (DKA). A 78-year-old man presented with a one-week history of flu-like symptoms and lower back pain. He had a history of type 2 diabetes, and had been started on an SGLT 2 inhibitor. He was found to ...

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ea0104p84 | Diabetes & Metabolism | SFEIES24

Implementation of diabetic ketoacidosis guidelines and its impact on patient outcomes

Abraham Anu , Duggal Manbir , Govindaraj Sureshkumar Ragavendran , Kempegowda Punith

Introduction: Revised guidelines by the Joint British Diabetes Society-Inpatient (JBDS-IP) recommend reducing the fixed rate intravenous insulin infusion (FRIII) from 0.1 to 0.05 units/kg/hour and starting 10% glucose at 125 ml/hour when blood glucose levels fall below 14 mmol/l.Aim: This study evaluates trends in implementation, associated outcomes with the revised JBDS-IP guidelines for DKA management in the UK.Methods: A retrosp...

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ea0104p85 | Diabetes & Metabolism | SFEIES24

A novel bipyrazole compound as a potential therapeutic agent for diabetes mellitus through PGK1/AKT activation

Alqudah Abdelrahim , Qnais Esam , Abu-Safieh Kayed , Gammoh Omar , Wedyan Mohammed , Alqudah Mohammed

Background: Diabetes mellitus type 2 (T2D) is a prevalent metabolic disorder characterized by insulin resistance and high blood sugar levels. Existing treatments focus on managing these symptoms, but there is an ongoing need for more effective interventions. Our study explores the potential of 2′,3,3,5′-Tetramethyl-4′-nitro-2′H-1,3′-bipyrazole (TMNB) in this context, based on its presumed impact on oxidation, glycation, and insulin resistance proc...

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ea0104p86 | Diabetes & Metabolism | SFEIES24

Audit on diabetic ketoacidosis (DKA) management in county hospital navan

Saiyid Hadi , Asif Khan M , Akram Khan Muhammad , Sardar Arzoo , Nawaz Khan Azher , Sajjad Hamza , Faraz Rafey Mohammed , Shah Shabahat

Introduction: DKA is a fatal complication of diabetes mellitus, if not treated appropriately. In hospital guideline on management of DKA has been developed in Our ladys hospital Navan and updated last in 2019.Aim: To assess the adherence of DKA guideline in our hospital and to assess the complexity of medical admissions with DKA in our hospital.Methods: We collected retrospective data for our audit and prospective data on our...

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ea0104p87 | Diabetes & Metabolism | SFEIES24

Clinical audit on awareness among doctors of a county hospital navan on diabetes and rules of driving

Sardar Arzoo , Nawaz Khan Azher , Akram Khan Muhammad , Sajjad Hamza , Ryan Caoimhe C. , Faraz Rafey Mohammed , Shah Shabahat

Introduction: Hypo-glycaemia awareness and education on rules of driving are paramount in patients who are on regular insulin and are driving currently. It is the responsibility of the prescribing physician to make sure that patients who are prescribed insulin are educated on the rules of driving.Aim: To assess and educate the doctors of a county hospital, on implications of hypo-glycaemia on driving and to update them on the national driving licence ser...

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ea0104p88 | Diabetes & Metabolism | SFEIES24

Insulin-releasing and glucose-lowering effects of gallic acid in cellular and high fat-fed mice models of type 2 diabetes

Ojo Opeolu , Falana Ayokunle , Falobi Ayodele , Heer Simren , Adie Mojisola , Edeani Joy , Ojo Constance

Aim: Gallic acid is one of the major bioactive phenolic compounds that have been isolated from several plant extracts with reported antidiabetic actions. However, insulinotropic effects and mechanisms underlying antidiabetic actions of garlic acid is poorly understood. This study investigated insulin-releasing and glucose-lowering effects of gallic acid.Methods: Glucose-stimulated insulin secretion in BRIN-BD11 cells were examined in the absence or prese...

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ea0104p89 | Diabetes & Metabolism | SFEIES24

Outcomes of real-time continuous glucose monitoring in adults with type 1 diabetes - quality improvement in diabetes care in a regional diabetes service in Ireland

Nicholas Colina , Doyle Georgina , McCormack Michelle , McGarry Catherine , Borlle Julen , Sharma Jayant , Pyeh Kyithar Ma

Background: NICE 2022 updated guidelines and the updated Irish guidelines (launched on 10th May 2024) in type 1 diabetes (T1D) in adults recommend the use of continuous glucose monitoring (CGM) based on individual preferences and needs. This study aimed to evaluate the outcomes of Dexcom real-time CGM (rt-CGM) in adults with T1D attending our regional diabetes service.Methods: A retrospective data analysis was conducted from the Dexcom Clarity...

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ea0104p90 | Diabetes & Metabolism | SFEIES24

CCR5 activation stimulates adipocyte differentiation through ERK-dependent pathway

Chen Luen-Kui , Wu Shao-Yun , Juan Chi-Chang

Obesity is associated with low-grade chronic inflammation. Studies demonstrated that RANTES and CCR5 mRNA levels were significantly increased in visceral adipose tissue of obese patients compared with lean control. However, the role of CCR5 activation on pathogenesis of obesity is not clear. The purpose of this study is to explore the effects of CCR5 activation on adipogenesis and its underlying regulatory mechanisms. 3T3-F442A preadipocytes and primary preadipocytes isolated ...

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ea0104p91 | Diabetes & Metabolism | SFEIES24

Characterization of plasma free amino acid profile in patients with type one diabetes in jordan

Qnais Esam , Wedyan Mohd , Alqudah Abdelrahim

Type 1 diabetes mellitus (T1DM), typically emerging in childhood, is an autoimmune condition where T cells destroy insulin-producing islet β cells in the pancreas. Chronic hyperglycemia from diabetes results in significant organ damage, including the kidneys, eyes, nerves, heart, and blood vessels. The study of plasma-free amino acids (PFAA) profiles in T1DM within the Jordanian population is scant and not well-documented. This research analyzed the PFAA profiles in Jorda...

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ea0104p92 | Diabetes & Metabolism | SFEIES24

Investigation of the mechanism underlying the antidiabetic actions of extracts of Ocimim basilicum

Falana Ayokunle , Falobi Ayodele , Kaur Simren , Edeani Joy , Adie Moji , Ojo Opeolu

Aim: Ocimum basilicum extract is used traditionally for type 2 diabetes treatment in developing countries. Studies have reported antidiabetic properties of aqueous and methanolic extracts of O. basilicum but mechanisms underlying these actions are not fully understood.Methods: Insulin-releasing effect of O. basilicum extract (0.1 1000µg/ml) were investigated using BRIN-BD11 cells. Effects of the extract (100µg/...

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ea0104p93 | Diabetes & Metabolism | SFEIES24

Role of cannabinoid type 2 receptor in white adipocyte browning

Ku Huei-Cih , Juan Chi-Chang

The browning of white adipocytes can increase energy expenditure through the activity of uncoupling protein 1 (UCP1) located on the mitochondrial inner membrane. The endocannabinoid (EC) system, composed of endogenous cannabinoids and cannabinoid receptors, has been shown to regulate energy balance in the body. A previous research has demonstrated that blocking the cannabinoid type 1 receptor (CB1R) causes white adipocyte browning. However, the mechanism of the EC system regul...

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ea0104p94 | Diabetes & Metabolism | SFEIES24

Does technology help? inpatient hypoglycaemia: potential benefits of an electronic insulin management solution

Maraj Rayanna , Crawley Niall , Ambreen Asma , O'Murchadha Liam , Kelly Sinead , Roche Eimear , Relihan Eileen , Phelan Niamh

Hypoglycaemia in hospitalised patients with Diabetes is common, confers higher morbidity/mortality, prolongs length-of-stay and increases re-admission rates. Previous audit identified adequate initial treatment of hypoglycaemia but poor subsequent management risking recurrent episodes. In March 2023, insulin prescribing moved from paper-based to an electronic medicines management process in line with other medication prescriptions in our institution. An alert for electronic pr...

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ea0104p95 | Diabetes & Metabolism | SFEIES24

Plasma free amino acids profiling in jordanian patients with hypertension and type 2 diabetes mellitus

Wedyan Mohammed , Qnais Esam , Alqudah Abdalrahim

Lifestyle-related disorders such as metabolic syndrome, diabetes mellitus (DM), dyslipidemia, and hypertension are key contributors to cardiovascular diseases. The interplay of diabetes and hypertension significantly affects the progression of atherosclerotic cardiovascular disease. Amino acids vary chemically based on their side chains, classifying them into acidic, basic, and neutral groups. Alterations in amino acid metabolism are critically involved in disease pathogenesis...

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ea0104p96 | Diabetes & Metabolism | SFEIES24

A study of referral patterns and patient characteristics observed in Ireland’s first fully functional community hub diabetes service during its inaugural year of operation

de Jong Katie , Kyaw-Tun Tommy , McDermott John , Sreenan Seamus , Davenport Colin

Enhanced community care (ECC) for type 2 diabetes mellitus (T2DM) is a new initiative in Ireland. ECC involves episodic community-based consultant-led multidisciplinary care that supports general practitioner (GP)-delivered chronic disease management (CDM, available to patients with a medical or GP visit card). The Dublin North West (DNW) hub was the first fully operational hub. This study focuses on its inaugural year of activity. The study goals were to report on hub referra...

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ea0104p97 | Diabetes & Metabolism | SFEIES24

Glucosamine increases FGF21 expression through Akt-mTOR-p70S6K axis-induced endoplasmic reticulum stress response in skeletal muscle cells

Liu Shui-Yu , Juan Chi-Chang

Glucosamine (GlcN) is a common supplement that is widely used to improve osteoarthritis, but it would impair myogensis through endoplasmic reticulum (ER) stress eIF2α-ATF4 pathway. Fibroblast growth factor 21 (FGF21) is one of muscle-secreted cytokine that participates in the myogenic differentiation. The Akt-mTOR-p70S6K axis play a pivotal role in protein synthesis, while sustained activation in mTOR signaling that triggers ER stress and conducts FGF21 production in skel...

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ea0104p98 | Diabetes & Metabolism | SFEIES24

Changes in development and function of skeletal muscle in UCP-1 knockout mice

Chang Yi-Chieh , Juan Chi-Chang

Brown adipose tissue (BAT) and skeletal muscle are play vital roles in the regulation of thermogenesis. In addition to thermogenesis through muscle activity, heat can be produced by non-shivering thermogenesis of BAT to produce heat. The heat production of BAT is dependent on the activity of uncoupling protein 1 (UCP1), which generates heat by dissipating the mitochondrial proton gradient. Recent studies suggested that UCP1 deficiency might cause the compensatory thermogenesis...

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ea0104p99 | Diabetes & Metabolism | SFEIES24

Differential impact of GLP-1 and GLP-2 on beta-cell function, glucose metabolism, and appetite

Ali Asif , Khan Dawood , Irwin Nigel , Flatt Peter R.

Background: Glucagon-like peptide-1 (GLP-1) and glucagon-like peptide-2 (GLP-2), are key products of the L-cell proglucagon-gene with diverse effects on metabolism. Whereas GLP-1 has been extensively studied, much less attention has been devoted to GLP-2. The current study directly compares the impact of GLP-1 and GLP-2 on pancreatic beta-cell function and turnover in vitro, as well as the effects on glucose tolerance and appetite suppression in mice.<p class="abs...

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ea0104p100 | Diabetes & Metabolism | SFEIES24

An audit of c-peptide testing in a university teaching hospital: are we meeting recommended standards?

Ryan Laura , O'Brien Clare , Heverin Karen , Reeve Janice , Griffin Damian , Dinneen Sean

C-peptide is a marker of pancreatic beta cell function and is used to investigate hypoglycaemic disorders and aid diabetes classification. An international consensus report (ADA/EASD) on the management of type 1 diabetes recommends C-peptide (with concurrent glucose) measurement, in individuals 3 years after diagnosis where there is uncertainty about diabetes classification. We conducted a retrospective audit of C-peptide testing among adult patients in Galway University Hospi...

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ea0104p101 | Diabetes & Metabolism | SFEIES24

Validation of gestational diabetes mellitus diagnosis in electronic health records

Germaine Mark , O'Higgins Amy , Healy Graham , Egan Brendan

Objective: To assess the accuracy of gestational diabetes mellitus (GDM) diagnoses in electronic health records (EHRs) by comparing them to a real-time clinical team database maintained by the hospital.Methods: The study employed a retrospective validation design to evaluate the accuracy of GDM diagnoses in the EHRs of The Coombe Hospital, Dublin. Patient IDs were matched between the EHR system and a real-time clinical team database (GDM Val) which recor...

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ea0104p102 | Diabetes & Metabolism | SFEIES24

Histological analysis of debrided tissue from chronic ulcers in people with diabetes mellitus

Soltan Merhan , Carroll John , Daly Eimear , Fortune Kellie , Siddique Najia , Davenport Colin , Kyaw Tun Tommy , McDermott John H. , Quondamatteo Fabio , Sreenan Seamus

Chronic ulcers represent very common and serious complications of diabetes mellitus. Their persistence leads to repeated infections, often leading to amputation. The current state-of-the art treatment includes debridement which is aimed at preparing the wound bed and stimulating ulcer edges to trigger tissue regeneration. We aimed to test the hypothesis that features of the debrided tissue may be indicative of the natural evolution of the wound. As a first step for this charac...

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ea0104p103 | Diabetes & Metabolism | SFEIES24

No effect of liraglutide, dulaglutide or danuglipron on in-vitro aggregation and activation of platelets from healthy subjects

Prem Kumar Anusha , Sreenan Seamus , Brennan Marian

Glucagon-Like Peptide 1 receptor agonists (GLP1RAs) have been shown to lower the risk of cardiovascular events and death in people with type 2 diabetes at high cardiovascular risk. Danuglipron, is a small molecule peptide agonist of the GLP1 receptor, a novel drug class of oral medication with promising effects on improving glycaemic control and promoting weight loss in people with diabetes or obesity. Due to the early cardiovascular risk reduction observed in some GLP1RA card...

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ea0104p104 | Diabetes & Metabolism | SFEIES24

Planning for recruitment and retention in the D1 now randomised controlled trial -a re-audit of a young adult cohort with type 1 diabetes

Casey Caoimhe , Lakshminarayanan Aarya , Cunningham Aine , Surendran Aswathi , Dinneen Sean

Introduction: The D1 Now study was established to improve outcomes for young people with type 1 diabetes. The D1 now intervention focuses on making the clinic visit more young person-centred through enabling young people to set their agenda, and use of a support worker as a liaison. An audit of the young adult cohort attending University Hospital Galway (UHG) in 2011 showed suboptimal glycaemic control and high rates of unscheduled emergency visits and non-attendance ...

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ea0104p105 | Diabetes & Metabolism | SFEIES24

Management of enteral and parenteral nutrition in inpatients with diabetes in an Irish tertiary referral centre

Dunleavy Therese , Kilcoyne Ciara , Melvin Audrey , Noctor Eoin

Introduction: Recent consensus guidelines for the Joint British Diabetes Societies and the Endocrine Society cover the common clinical scenario of optimising glycaemic control in patients receiving enteral (NG/PEG), and total parenteral nutrition (TPN), although the approach recommended differs. Here, we outline an Irish tertiary referral centre experience, and compare with international guidance.Methods: We extracted data from our electronic referral sy...

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ea0104p106 | Diabetes & Metabolism | SFEIES24

An intentional overdose of ultra-long-acting insulin analogue complicated by treatment refusal in a patient with mixed personality disorder and type 2 diabetes mellitus

Carr James , Khan Farooq , Ryan James

Diabetes Mellitus is one of the leading causes of morbidity and healthcare costs internationally. Innovations in treatment options however, including insulin analogues, continue to emerge. While insulin therapy may be required for certain patients with Type 2 Diabetes Mellitus (T2DM), it bestows upon them the opportunity for potential harm, namely insulin overdoses, whether accidental or intentional. This case details an intentional ultra-long-acting insulin analogue overdose ...

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ea0104p107 | Diabetes & Metabolism | SFEIES24

Introduction of an online glucose monitoring system for management of gestational diabetes in cork university maternity hospital – a pilot study

Wyse Adrianne , Wing Norma , Manning Jacqueline , Lane Patricia , Nolan Louise , O'Mahony Louise , Louise Moynihan Emma , O'Riordan Mairead , Kgosidialwa Oratile

The prevalence of gestational diabetes mellitus (GDM) is increasing worldwide and is currently 12% (appx. 800 women/annum) in our institution with 40% of the patients requiring treatment with insulin. The aim of this project is to assess if the use of an online glucose management platform in addition to usual care would improve patient satisfaction in women with GDM. Patients diagnosed with GDM were randomised to the use of Bluetooth enabled Onetouch Verion or...

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ea0104p108 | Diabetes & Metabolism | SFEIES24

Exploring the role of mitochondria-endoplasmic reticulum contact sites in bile acid synthesis

Potter Tom , Bailey Maira , Tomlinson Jeremy , Gathercole Laura

Mitochondria-endoplasmic reticulum contact sites (MERCS) play a key role in cholesterol metabolism and steroidogenesis by facilitating the efficient transfer and processing of cholesterol for steroid hormone synthesis. However, whether MERCS play a role in bile acid synthesis is completely unexplored. Here we begin to investigate a role for MERCS in bile acid synthesis using two alternative models of MERCS disruption. First, to reduce the total number of MERCS we performed siR...

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ea0104p109 | Diabetes & Metabolism | SFEIES24

Corynebacterium sp. in diabetic foot ulcers – a retrospective, single-centre, observational descriptive study from a tertiary hospital

Lockhart Michael , O'Doherty Laura , Gallagher David

Introduction: Corynebacterium sp. has long been understood to be a colonising bacteria in diabetic foot infections. We present a retrospective study to describe the experience of Corynebacterium sp. in a cohort of inpatients with active diabetic foot disease (DFD) in a tertiary referral centre.Methods: We included all inpatients attending our tertiary referral centre who were admitted with a DFD-related complaint and who were seen on th...

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ea0104p110 | Diabetes & Metabolism | SFEIES24

A case of insulin autoimmune syndrome (hirata disease) - a rare cause of hypoglycaemia

Brain Eleanor , Chambers Tom

Background: Insulin autoimmune syndrome (Hirata disease) is a very rare cause of hypoglycaemia; approximately 400 cases have been described. The presence of insulin autoantibodies leads to the formation of insulin-Ig complexes, with subsequent dissociation of insulin resulting in episodes of severe hypoglycaemia. The condition can present a diagnostic and management challenge.Case Report: A 77-year-old man was attended by paramedics with a GCS of 8 and s...

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ea0104p111 | Diabetes & Metabolism | SFEIES24

GPR120/GPR40 agonism activates downstream signalling molecules that improve beta cell function and insulin resistance in type 2 diabetes

McGinn Dearbhla , Owolabi Adeoluwa , Corbett Reece , Tarasov Andrei , Flatt Peter , McKillop Aine

Background: G-Protein Coupled Receptors-120 (GPR120) and GPR40 are of interest as targets for treating diabetes and obesity due to their involvement in incretin secretion. This study investigated the mechanistic function of dual agonism on regulating the regeneration of beta cell mass, proliferation, and the insulin secretory response, using CRISPR/Cas9 gene knockout cells and intracellular-signalling analysis.Methods: Clonal pancreatic BRIN-BD11 cells a...

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ea0104p112 | Diabetes & Metabolism | SFEIES24

A real-world, single-centre experience of vascular specialist input on the multidisciplinary diabetic foot round in a tertiary hospital – an observational study

Lockhart Michael , Young Ellen , Kelly Colm , Cahill Conor , O'Shea Katie , Reddington Lisa , Pandian Arunabai , Joyce Doireann , Cremen Sinead , Tubassam Muhammad , O'Loughlin Aonghus , Gallagher David , Dinneen Sean

Introduction: Multidisciplinary Foot Team (MDFT) input is a cornerstone of best-practice guidelines for the management of active diabetic foot disease (DFD). This study describes the experience of the inpatient multidisciplinary DFD ward round (DFR) in our hospital over two three-month periods, one year apart.Methods: We prospectively captured data from the DFR in our hospital over two three-month periods, one year apart. This weekly DFR reviews inpatien...

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ea0104p113 | Diabetes & Metabolism | SFEIES24

Relative energy deficiency in sport in female gaelic athletic association players

Wyse Adrianne , Connell Louise O. , Fitzgerald Rachel , Connor Patrick O. , Powell Caleb , O' Flynn Bernadette , Kealy Michelle , Murphy Billy , Courtney Aoife , Bransfield Alison , McCarthy Kelly , Clarke Denise , Costelloe Sean , McCarthy Elaine , Leary Paula O. , Tuthill Antoinette

Relative Energy Deficiency in Sport (RED-S) is a syndrome caused by low energy availability (LEA), where an athletes energy intake is inadequate to match expenditure. In 2023 the International Olympic Committee released a consensus statement for REDS, with recommendations for studying health outcomes. 1 Our study aims to investigate if elite female Gaelic Athletic Association (GAA) players are at risk of LEA and RED-S. 44 female intercounty GAA players were re...

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ea0104p114 | Diabetes & Metabolism | SFEIES24

The importance of identifying the correct type of diabetes: a rare case of bardet-biedl syndrome type 3

Bonanos Stathis , McConnell Mae

Bardet-Biedl affects 1/100,000 people. Biallelic loss of function pathogenic variants in over 26 genes may be due to autosomal recessive inheritance. Diagnosis is clinical, with genetic testing confirmation. Presenting features include retinal cone-rod dystrophy, obesity, polydactyly, cognitive impairment, hypogonadism, genitourinary abnormalities, monogenic diabetes, hypothyroidism, polycystic ovarian and metabolic syndrome. We present a rare case of Bardet-Biedl type 3, with...

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ea0104p115 | Diabetes & Metabolism | SFEIES24

AKR1D1 plays a critical role in the progression of MASLD: Evidence from in vitro and in vivo studies

Bailey Maira , Nikolaou Nikolaos , Harris Shelley , Potter Tom , Tomlinson Jeremy , Gathercole Laura

Bile acid (BA) homeostasis is disrupted in MASLD with characteristic changes in BA pool composition. BAs are signalling molecules that modulate hepatic lipid metabolism, inflammation, and cellular proliferation via the activation of nuclear receptors, notably FXR. Altered FXR activation has profound effects on the transcription of genes involved in hepatoprotection. We have previously shown that the hepatic enzyme 5β-reductase (AKR1D1), which catalyses a key step...

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ea0104p116 | Diabetes & Metabolism | SFEIES24

Semaglutide intervention in overweight people with schizophrenia: the road back to better physical health - preliminary results from a feasibility study

Heald Adrian , Warner Levy John , Firth Joseph , Syed Akheel

Introduction: Weight gain and its associated adverse health consequences have become a significant aspect of the life experience of many people with schizophrenia and other severe enduring mental illnesses (SMIs). Glucagon-like peptide -1(GLP-1) receptor agonists could be of substantial value in addressing this unmet need. We aimed to determine whether semaglutide treatment is feasible and acceptable to individuals in an inpatient setting and successful in facilitating weight ...

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ea0104p117 | Diabetes & Metabolism | SFEIES24

The challenges of managing type 1 diabetes mellitus in the presence of dercum’s disease

Iftikhar Mishaal , Muneeb Ur Rahman Muhammad , Cain Emma , Liew Aaron

Although the prevalence and aetiology of Dercums disease (Adiposis Dolorosa) are currently unknown, this condition is most commonly diagnosed between the ages of 35 and 50 years and more common in women than in men. We described the challenges of the glycaemic management of a 44-year-old male who was diagnosed with Dercums disease about a decade after the diagnosis of Type 1 Diabetes Mellitus. Despite previous episodes of diabetic ketoacidosis, his Hba1c over the l...

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ea0104p118 | Diabetes & Metabolism | SFEIES24

Fulminant type 1 diabetes and autoimmune thyroid disease during treatment with a checkpoint inhibitor

Cadogan Sinead , Glynn Nigel

Atezolizumab, a programmed death-ligand 1 (PD-L1) inhibitor, has been associated with development of several immune-related adverse events. Type 1 diabetes mellitus (T1DM) is considered a rare adverse event, described in 0.2-0.9% of patients treated with PD-L1 inhibitors. We present the case of a 67-year-old lady, who was diagnosed with extensive-disease small cell lung cancer. She received four cycles of carboplatin, etoposide and atezolizumab, and thereafter maintenance ther...

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ea0104p119 | Diabetes & Metabolism | SFEIES24

Lower urinary tract dysfunction in the diabetic population: diabetes specialist’sknowledge base, clinic practice patterns and patient survey

Bowers Kevin , Khan Jody , Manecksha Rustom , Sullivan John , Owens Lisa

Introduction: Patients with Diabetes have a higher risk of lower urinary tract dysfunction/symptoms (LUTS) compared to those without diabetes. Causative factors include autonomic, detrusor, and urothelial dysfunction, microvascular ischaemic changes, and glycosuria. With a shift towards holistic diabetes management, this study examined whether urinary dysfunction is routinely addressed in outpatient settings and whether Diabetes speciality teams feel equipped to manage this is...

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ea0104p120 | Diabetes & Metabolism | SFEIES24

Switching to a hybrid closed-loop insulin system leads to reduction in mean hba1c levels in subjects with type 1 diabetes

Cadogan Sinead , Jane Lennon Sarah , O'Shea Helen , Byrne Maria

Objective: We examined our cohort of adults with type 1 diabetes who are using hybrid closed-loop (HCL) insulin delivery systems, to describe what proportion are meeting international targets of HbA1c, time-in-range, and time spent below range. We assessed longitudinal changes in HbA1c associated with switching from an open-loop to a HCL insulin pump.Methods: We undertook a single-centre observational study of patients using Medtronic 780G insulin ...

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ea0104p121 | Diabetes & Metabolism | SFEIES24

Novel mutation in the SLC5AC gene causing renal glucosuria and hypoglycaemia

Cadogan Sinead , Byrne Maria

Renal glucosuria is a rare cause of hypoglycaemia. We describe an 18-year-old female who presented with a 2-year history of recurrent episodes of light-headedness and headaches. Glucometer readings during these symptoms demonstrated hypoglycaemia as low 2.1 mmol/l. She also had a 4-year history of recurrent urinary tract infections. Multiple dipstick urinalyses with GP demonstrated glucosuria, which was quantified with a 24-hour urinary glucose elevated at 4g/1.73m 2</sup...

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ea0104p122 | Diabetes & Metabolism | SFEIES24

Case report: a case of severe insulin resistance due to antibodies specific for detemir

Yi Joyce Tan Lok , Morgan Elliot , Noctor Eoin

Insulin antibodies were common when animal insulin was used given its high immunogenicity. The advent of recombinant DNA technology in insulin production has reduced the incidence of insulin antibodies and its presence is rarely considered clinically significant. Exogenous Insulin Antibody Syndrome (EIAS) describes the formation of insulin antibodies to exogenous insulin. We present a case of a 65-year-old gentleman who was diagnosed with diabetes mellitus secondary to pancrea...

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ea0104p123 | Diabetes & Metabolism | SFEIES24

The NONcNZO10/ltJ polygenic mouse is ideal model to study de novo lipogenesis and modeling type 2 diabetes remission by weight loss

Kaluzny Szczepan , Zhang Lilian , Onishi Ami , Junior Jair , Von Kriegsheim Alex , Morton Nicholas , Al-Mrabeh Ahmad

Background and aims: Understanding the mechanisms that lead to remission of type 2 diabetes (T2D) after weight loss is critical to develop novel therapies. We hypothesized that weight loss decreases hepatic de novo lipogenesis (DNL), a primary mechanism expected to modulate T2D remission.Methods: 24 mice (NONcNZO10/ltJ) at age 5-6 weeks were placed for 12 weeks on high sucrose diet (HSD: 60% sucrose/20% fat). After 12 weeks, 6 mice were placed on calorie...

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ea0104p124 | Diabetes & Metabolism | SFEIES24

Protocol divergence in the management of diabetic ketoacidosis

Rebecca George Sara , Yerushalmy David , Morgan Elliot , Almezen May , bin Mahfooz Mohammed , Marie Hannon Anne , Noctor Eoin , Melvin Audrey

Diabetic Ketoacidosis (DKA) is a life threatening emergency and its management is frequently protocolised. Adherence to protocols has been shown to shorten the time to DKA resolution however the management recommendations outlined in most DKA protocols is based on weak evidence and/or consensus. The aim of this study was to evaluate the frequency with which divergence from local DKA protocol was observed at our institution. A retrospective review of medical records was conduct...

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ea0104p125 | Diabetes & Metabolism | SFEIES24

Unveiling hidden diabetes: a neuropathic foot ulcer as the first sign of type 2 diabetes mellitus in a post-menopausal woman

Ali Asad , Hamza Kang Chaudhary , Athar Khan Muhammad , Fernando Devaka

Diabetes mellitus (DM) is a prevalent chronic disease often diagnosed through routine screening or the manifestation of typical symptoms like polyuria and polydipsia. However, it is rare for diabetic neuropathic complications, such as foot ulcers, to be the initial presentation, especially in the absence of other medical conditions. This case report discusses a 53-year-old female who presented with a neuropathic foot ulcer, leading to the diagnosis of Type 2 Diabetes Mellitus ...

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ea0104p126 | Diabetes & Metabolism | SFEIES24

Novel unimolecular peptides targeting GLP-1 and APJ receptors exert potent satiety inducing effects in mice

Palmer Ethan , Craig Sarah , Irwin Nigel , O'Harte Finbarr

Incretin mimetics and associated hybrid co-agonist peptides remain a driving force in improving metabolic control and managing type 2 diabetes and obesity. Additionally, the adipokine apelin which targets the APJ receptor, has displayed positive anti-diabetic and obesity effects in pre-clinical trials. To harness these beneficial effects, two novel dual-agonist unimolecular peptides were developed based on the amino acid sequence of GLP-1 and apelin and named Exendin-Linker-Ap...

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ea0104p127 | Diabetes & Metabolism | SFEIES24

Healthcare costs and utilisation for diabetes mellitus among hospitalised patients in ireland: the national kidney disease surveillance system

Browne Leonard , Stack Austin

Background: Understanding the frequency, length of stay, and costs of inpatient hospitalization for diabetes mellitus (DM) is crucial for effective healthcare planning. This study examines these factors for diabetes-related hospitalisations in Ireland.Materials and Methods: A retrospective observational study was conducted using the National Hospital In-Patient Enquiry (HIPE) database. Non-coded hospitalisations and patients < 1 year were excluded. A...

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ea0104p128 | Diabetes & Metabolism | SFEIES24

Role of FKBP51 on the development of obesity-associated metabolic disorders

Juan Chi-Chang , Chen Luen-Kui

Abnormal adipogenesis and adipocyte dysfunctions have been suggested to be important mechanisms underlying the development of metabolic syndrome. Obesity is associated with a chronic, low-grade inflammation status. The pathogenic mechanisms at the molecular level in obesity-associated inflammation and insulin resistance are not fully understood and need to be elucidated. The 51 KD FK506-binding protein 51 (FKBP51), encoded by Fkbp5 gene, is one of the of immunophilin ...

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Joint Irish-UK Endocrine Meeting 2024

BiosciAbstracts