Searchable abstracts of presentations at key conferences in endocrinology
Previous issue | Volume 104 | SFEIES24

Joint Irish-UK Endocrine Meeting 2024

Belfast, Northern Ireland
14 Oct 2024 - 15 Oct 2024

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Poster Presentations

Endocrine Cancer & Late Effects

ea0104p129 | Endocrine Cancer & Late Effects | SFEIES24

IGF-2 mediated hypoglycemia in adrenocortical carcinoma: a case series

Lai Valerie , Desgagnes Noemie , Ghuttora Harleen , Yeo Caitlin , Mahajan Amita , Lithgow Kirstie

Non-islet cell tumor hypoglycemia (NICTH) is a rare phenomenon that is likely mediated by insulin growth factor 2 (IGF-2). IGF-2 excess results from tumor overproduction of either mature IGF-2 or incompletely processed IGF-2 (“big IGF-2”), which binds to the insulin receptor causing hypoglycemia. We present a case of IGF-2 mediated hypoglycemia secondary to adrenocortical carcinoma, as well as a series of 8 previously published cases. An 83-year-old male with a histo...

ea0104p130 | Endocrine Cancer & Late Effects | SFEIES24

Detection of BRAFV600E in thyroid cancer tissue using digital droplets PCR and whole exome sequencing

Al Jumaah Ali , Gohil Shailesh , Page Karen , Allsopp Rebecca , Reddy Narendra , Shaw Jacqui , Levy Miles

Introduction: The BRAF V600E mutation has been reported in 27– 90% of Papillary Thyroid Carcinoma (PTC). BRAF V600E may be associated with adverse outcomes in PTC. It is unknown if detection of BRAF V600E can play a key role in prognosis, and can be used as a surrogate-marker of poor outcomes in PTC.Objectives: • To investigate prevalence of BRAF V600E mutation in TC using digital droplet PCR (ddPCR)....

ea0104p131 | Endocrine Cancer & Late Effects | SFEIES24

A decade of abdominal paragangliomas in the northern ireland regional referral centre

Benjamin Loughrey Paul , Cvasciuc Titus , Rajendran Simon , Mullan Karen R. , Eatock Fiona , Hunter Steven J. , Morrison Patrick J. , Johnston Philip C.

Background: Paragangliomas are rare neuroendocrine tumours of the sympathetic and parasympathetic paraganglia. Optimal outcomes are dependent on careful investigation, management and follow-up.Aim: The aim of this audit was to review clinicopathological characteristics of a cohort of operated abdominal paragangliomas in Northern Ireland.Methods: This is a retrospective audit of abdominal paragangliomas from the Northern Ireland reg...

ea0104p132 | Endocrine Cancer & Late Effects | SFEIES24

Multiple endocrine dysfunctions associated with immune checkpoint inhibitors treatment: case report

Stoian Iulia , Spataru Mihaela , Sirbu Anca , Martin Sorina , Fica Simona

Background: Immune checkpoint inhibitors (ICI) are anti-cancer drugs associated with adverse events that results from releasing the immune system against self-antigens while attacking cancer cells. Multiple endocrine dysfunctions have been associated with administration, including hypophysitis, thyroid disorders and diabetes.Case report: We report the case of a 57-year-old female, diagnosed with melanoma of the left arm Barlow Depth 2 mm, receiving treat...

ea0104p133 | Endocrine Cancer & Late Effects | SFEIES24

Prevalence of hypopituitarism in survivors of adult onset, primary, non-pituitary, brain tumours treated with intensity-modulated radiotherapy

Mc Donald Darran , McDermott Niamh , Tomkins Maria , O'Connell Liam , Faul Clare , Fitzpatrick David , Thompson Chris , O'Reilly Michael W. , Sherlock Mark

Background: Intensity-modulated radiotherapy (IMRT) precisely delivers radiation to brain tumours while partially sparing surrounding structures like the hypothalamic-pituitary axis. The risk of hypopituitarism in survivors of adult-onset, primary, non-pituitary brain tumours following IMRT is poorly understood.Methods: We conducted a retrospective cohort study of brain tumour survivors undergoing endocrine surveillance in Beaumont Hospital. Patients wit...

ea0104p134 | Endocrine Cancer & Late Effects | SFEIES24

Evaluating human monocyte migration and co-culture with adrenocortical cancer cells

Hong Cong , Sorushanova Anna , O'Halloran Martin , Prakash Punit , Conall Dennedy Michael

Adrenocortical carcinoma (ACC) carries a 5-year prognosis of <10%. Therapeutic options are limited including surgery and mitotane – a poorly tolerated and efficacious insecticide. Recent data have demonstrated that the immune environment of ACC is deficient in lymphocytes while demonstrating a relative rich monocyte/macrophage population in the tumour microenvironment. We have investigated the migration of circulating monocytes to ACC. ACC cells were seeded in the bot...

ea0104p135 | Endocrine Cancer & Late Effects | SFEIES24

Successful pregnancy after radioiodine treatment for differentiated thyroid carcinoma - a case series

Trifanescu Raluca , Toma Iustin , Goldstein Andrei , Trifanescu Oana , Poiana Catalina

Background: Pregnancy outcome after radioiodine treatment for differentiated thyroid carcinoma (DTC) is debated. Some studies found a 23% infertility rate after radioiodine treatment. On the other hand, postoperative radioiodine therapy for DTC had no significant effect on spontaneous abortion, premature, stillbirth and congenital malformation.Aim: To access pregnancy outcome in a series of women with DTC treated with radioiodine postoperatively. <p ...

ea0104p136 | Endocrine Cancer & Late Effects | SFEIES24

Efficacy and safety of RET-kinase inhibitors in RET-altered thyroid cancer: A single arm meta-analysis

Jahan Israt , Jahan Ifrat

Background: RET proto-oncogene that encodes receptor tyrosine kinase is responsible for the pathogenesis of most of the thyroid cancer subtypes. Selpercatinib and pralsetinib, both specific RET-kinase inhibitors, are the only two FDA-approved drugs for RET-altered thyroid cancer. We aimed to evaluate the safety and efficacy of these two drugs.Methods: We searched PubMed, Embase, Cochrane and Clinicaltrials.gov databases for RCTs and observational studies...

ea0104p137 | Endocrine Cancer & Late Effects | SFEIES24

Using a combination of bulk and single cell RNA sequencing to identify transcriptomic differences in metastatic vs non-metastatic phaeochromoctyomas and paragangliomas

Quinn Mark , Brempou Dimitria , Izatt Louise , Carroll Paul , Oakey Rebecca

Introduction: Phaeochromocytomas and paragangliomas (PPGLs) are rare neuroendocrine tumours that are inherited in at least 40% of cases. The most common pathogenic germline variants (PGVs) implicated in the development of PPGLs are in genes coding for the subunits of succinate dehydrogenase (SDH). PPGLs are heterogenous tumours that have a variable clinical phenotype. Rates of metastatic disease varies from 5-40%. This variability is not currently understood. All patients iden...